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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

Smr  -  Smrter

Drosophila melanogaster

Synonyms: CG12719, CG4013, Dmel\CG4013, E52, SMR, ...
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High impact information on Smr

  • Sno binds to Su(H), and Ebi, an F-box/WD40 protein, forms a complex with Su(H) and the corepressor SMRTER [1].
  • Importantly, we identify an EcR mutant allele that fails to bind SMRTER and is characterized by developmental defects and lethality [2].
  • We describe a mechanism by which the Ebi/SMRTER corepressor complex maintains Dl expression [3].
  • Chromatin binding of the complex, mediated by SMRTER, decreased upon ecdysone-induced transcriptional activation but was restored when transcription was reduced [4].
  • Consistently, the neurodegenerative eye phenotype caused by mutant Atx1 is enhanced by a Smrter mutation and, conversely, is suppressed by a chromosomal duplication that contains the wild type Smrter gene [5].

Biological context of Smr


Other interactions of Smr

  • Here, we report the isolation of an EcR-interacting protein, SMRTER, which is structurally divergent but functionally similar to the vertebrate nuclear corepressors SMRT and N-CoR [2].
  • Host cell factor and an uncharacterized SANT domain protein are stable components of ATAC, a novel dAda2A/dGcn5-containing histone acetyltransferase complex in Drosophila [7].


  1. An EGFR/Ebi/Sno pathway promotes delta expression by inactivating Su(H)/SMRTER repression during inductive notch signaling. Tsuda, L., Nagaraj, R., Zipursky, S.L., Banerjee, U. Cell (2002) [Pubmed]
  2. SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development. Tsai, C.C., Kao, H.Y., Yao, T.P., McKeown, M., Evans, R.M. Mol. Cell (1999) [Pubmed]
  3. An NRSF/REST-like repressor downstream of Ebi/SMRTER/Su(H) regulates eye development in Drosophila. Tsuda, L., Kaido, M., Lim, Y.M., Kato, K., Aigaki, T., Hayashi, S. EMBO J. (2006) [Pubmed]
  4. Chromosomal localization links the SIN3-RPD3 complex to the regulation of chromatin condensation, histone acetylation and gene expression. Pile, L.A., Wassarman, D.A. EMBO J. (2000) [Pubmed]
  5. Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors. Tsai, C.C., Kao, H.Y., Mitzutani, A., Banayo, E., Rajan, H., McKeown, M., Evans, R.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  6. The SIN3/RPD3 deacetylase complex is essential for G(2) phase cell cycle progression and regulation of SMRTER corepressor levels. Pile, L.A., Schlag, E.M., Wassarman, D.A. Mol. Cell. Biol. (2002) [Pubmed]
  7. Host cell factor and an uncharacterized SANT domain protein are stable components of ATAC, a novel dAda2A/dGcn5-containing histone acetyltransferase complex in Drosophila. Guelman, S., Suganuma, T., Florens, L., Swanson, S.K., Kiesecker, C.L., Kusch, T., Anderson, S., Yates, J.R., Washburn, M.P., Abmayr, S.M., Workman, J.L. Mol. Cell. Biol. (2006) [Pubmed]
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