High impact information on ebi

• An EGFR/Ebi/Sno pathway promotes delta expression by inactivating Su(H)/SMRTER repression during inductive notch signaling [1].
• Sno binds to Su(H), and Ebi, an F-box/WD40 protein, forms a complex with Su(H) and the corepressor SMRTER [1].
• Similarly, in the developing eye, ebi promotes EGFR-dependent down-regulation of Tramtrack88, an antagonist of neuronal development [2].
• Mutations in ebi and Egfr lead to similar phenotypes and show genetic interactions [2].
• The Ebi/SMRTER corepressor complex represses chn transcription by competing with the activation complex that includes the Notch intracellular domain (NICD) [3].

Biological context of ebi

• Ectopic expression of Ttk88 inhibited differentiation in embryos and eye discs; however, this block to differentiation was insufficient to promote S phase entry in either of the situations where ebi mutations gave this effect [4].
• A role for Ebi in neuronal cell cycle control [4].
• The RING domain protein Sina, together with Phyllopod and the F-box protein Ebi, forms a Ras-regulated E3 ubiquitin ligase complex that activates photoreceptor cell differentiation in the eye of Drosophila melanogaster [5].

Regulatory relationships of ebi

• ebi regulates epidermal growth factor receptor signaling pathways in Drosophila [2].

Other interactions of ebi

• A new study has revealed a serial linkage between them, via Ebi and Strawberry Notch, which is important in determining the cone cell fate in the Drosophila eye [6].

References