Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

gyrB - DNA gyrase subunit B

Campylobacter jejuni RM1221

Taylor, D.E. et al., Bachoual, R. et al.

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Disease relevance of gyrB

All Campylobacter species were resistant to novobiocin (MIC, 32 to 512 micrograms/ml), but most strains were susceptible to the other DNA gyrase subunit B inhibitors coumermycin A1 and clorobiocin [1].

High impact information on gyrB

It carried a gyrA mutation leading to a Thr86-Ile substitution and was devoid of gyrB mutation [2].

Biological context of gyrB

This phenotype was not explained by the presence of peculiar mutations in gyrA or gyrB [2].

References

Susceptibility of Campylobacter species to nalidixic acid, enoxacin, and other DNA gyrase inhibitors. Taylor, D.E., Ng, L.K., Lior, H. Antimicrob. Agents Chemother. (1985) [Pubmed]
Single or double mutational alterations of gyrA associated with fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coli. Bachoual, R., Ouabdesselam, S., Mory, F., Lascols, C., Soussy, C.J., Tankovic, J. Microb. Drug Resist. (2001) [Pubmed]

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