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Gene Review

upd2  -  unpaired 2

Drosophila melanogaster

Synonyms: CG5988, Dmel\CG5988, UPD2, Upd-like, Upd2, ...
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High impact information on upd2

  • We show that upd2 is expressed in a pattern essentially identical to that of upd and demonstrate that the proteins encoded by this region activate JAK/STAT pathway signalling [1].
  • Characterisation of Upd2, a Drosophila JAK/STAT pathway ligand [1].

Other interactions of upd2

  • The stimulatory effect of upd2 on the JAK/STAT reporter can also be demonstrated in Drosophila tissue culture cells [2].


  1. Characterisation of Upd2, a Drosophila JAK/STAT pathway ligand. Hombría, J.C., Brown, S., Häder, S., Zeidler, M.P. Dev. Biol. (2005) [Pubmed]
  2. A novel functional activator of the Drosophila JAK/STAT pathway, unpaired2, is revealed by an in vivo reporter of pathway activation. Gilbert, M.M., Weaver, B.K., Gergen, J.P., Reich, N.C. Mech. Dev. (2005) [Pubmed]
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