Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

upd2 - unpaired 2

Drosophila melanogaster

Synonyms: CG5988, Dmel\CG5988, UPD2, Upd-like, Upd2, ...

Hombría, J.C. et al., Gilbert, M.M. et al.

Hombría, Brown, Häder, Zeidler,

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High impact information on upd2

We show that upd2 is expressed in a pattern essentially identical to that of upd and demonstrate that the proteins encoded by this region activate JAK/STAT pathway signalling [1].
Characterisation of Upd2, a Drosophila JAK/STAT pathway ligand [1].

Other interactions of upd2

The stimulatory effect of upd2 on the JAK/STAT reporter can also be demonstrated in Drosophila tissue culture cells [2].

References

Characterisation of Upd2, a Drosophila JAK/STAT pathway ligand. Hombría, J.C., Brown, S., Häder, S., Zeidler, M.P. Dev. Biol. (2005) [Pubmed]
A novel functional activator of the Drosophila JAK/STAT pathway, unpaired2, is revealed by an in vivo reporter of pathway activation. Gilbert, M.M., Weaver, B.K., Gergen, J.P., Reich, N.C. Mech. Dev. (2005) [Pubmed]

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