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Gene Review

Stat92E  -  Signal-transducer and activator of...

Drosophila melanogaster

Synonyms: CG4257, D-STAT, D-Stat, D-stat, D-stat/stat92E, ...
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Disease relevance of Stat92E


High impact information on Stat92E


Biological context of Stat92E

  • An analysis of mosaic clones, using an apparent null stat92E allele, indicates that Stat92E is required in the polar/stalk follicle cell lineage [8].
  • Here we identify Drosophila Stat92E (signal transducer and activator of transcription) in a screen for gain-of-function suppressors of the slbo mutant phenotype [9].
  • However, Stat92E mutant cells still express normal levels of Slbo protein, thus Stat92E must regulate other targets critical for border cell migration [9].
  • These constructs differ by the number of Stat92E binding sites and the stability of GFP [10].
  • Altogether, our data indicate that Dome is an essential receptor molecule for Upd and JAK/STAT signaling during oogenesis [11].

Anatomical context of Stat92E

  • Genetic analysis of contributions of dorsal group and JAK-Stat92E pathway genes to larval hemocyte concentration and the egg encapsulation response in Drosophila [12].
  • One of these mutants, statHJ, mapped to the same chromosomal region (92E) as does D-Stat, had an incompletely penetrant pair rule phenotype, and exhibited aberrant expression of the pair rule gene even skipped (eve) at the cellular blastoderm stage [3].
  • In Drosophila, a conserved JAK/STAT signaling pathway controls segmentation in embryos, as well as blood cell development and other processes in larvae and adults [11].
  • We demonstrate that mutants for domeless or any other known component of the canonical JAK/STAT signaling pathway display a failure of coordinated cell movement during the development of the proventriculus, a multiply folded organ which is formed by stereotyped cell rearrangements in the posterior foregut [13].
  • Taken together with the appearance of STAT92E in a gradient in the hindgut epithelium, these results support a model in which an anteroposterior gradient of ligand results in a gradient of activated STAT [14].

Associations of Stat92E with chemical compounds


Physical interactions of Stat92E

  • The JAK/STAT signaling pathway plays important roles in vertebrate development and the regulation of complex cellular processes [17].
  • We also found that the D-STAT-binding site is required for injury-induced activation of the D-raf gene promoter [15].
  • In addition, mutations in the Jak/STAT pathway interact genetically with the Notch pathway by suppressing Notch mediated overgrowth [18].

Regulatory relationships of Stat92E

  • Conversely, wg is autonomously repressed in cells with hyperactivated Stat92E [19].
  • Here we propose that D-STAT can participate in regulation of the mitogen-activated protein kinase cascade through D-raf gene activation [15].
  • Both the lethality and the eye roughening caused by activated Dsrc were partially suppressed by mutations in the Drosophila Ras1 gene [1].
  • SOCS36E is expressed in an essentially identical pattern to the Drosophila JAK/STAT pathway ligand unpaired (Upd) [20].
  • Recently we have shown that in Drosophila the receptor tyrosine kinase Torso activates both STAT and Ras during the early phase of PGC development [21].

Other interactions of Stat92E

  • In addition, these reporters accurately reflect JAK/STAT pathway activity at larval stages, as their expression pattern overlaps that of the activating ligand unpaired in imaginal discs [10].
  • Cooperation of JAK/STAT and Notch signaling in the Drosophila foregut [13].
  • Larvae carrying loss-of-function mutations in dorsal group genes (including Toll and tube) have reduced hemocyte concentrations, whereas larvae deficient in Hopscotch-Stat92E signaling do not [12].
  • Taken together, our study is the first to demonstrate a role for the JAK/STAT pathway in regional specification by acting antagonistically to wg [19].
  • We show that upd2 is expressed in a pattern essentially identical to that of upd and demonstrate that the proteins encoded by this region activate JAK/STAT pathway signalling [22].

Analytical, diagnostic and therapeutic context of Stat92E


  1. Ras1-dependent signaling by ectopically-expressed Drosophila src gene product in the embryo and developing eye. Kussick, S.J., Basler, K., Cooper, J.A. Oncogene (1993) [Pubmed]
  2. White spot syndrome virus annexes a shrimp STAT to enhance expression of the immediate-early gene ie1. Liu, W.J., Chang, Y.S., Wang, A.H., Kou, G.H., Lo, C.F. J. Virol. (2007) [Pubmed]
  3. Identification of a Stat gene that functions in Drosophila development. Yan, R., Small, S., Desplan, C., Dearolf, C.R., Darnell, J.E. Cell (1996) [Pubmed]
  4. Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs. Hou, X.S., Melnick, M.B., Perrimon, N. Cell (1996) [Pubmed]
  5. Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. Baeg, G.H., Zhou, R., Perrimon, N. Genes Dev. (2005) [Pubmed]
  6. mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family. Chen, H.W., Chen, X., Oh, S.W., Marinissen, M.J., Gutkind, J.S., Hou, S.X. Genes Dev. (2002) [Pubmed]
  7. Negative regulation of STAT92E by an N-terminally truncated STAT protein derived from an alternative promoter site. Henriksen, M.A., Betz, A., Fuccillo, M.V., Darnell, J.E. Genes Dev. (2002) [Pubmed]
  8. The Drosophila STAT protein, stat92E, regulates follicle cell differentiation during oogenesis. Baksa, K., Parke, T., Dobens, L.L., Dearolf, C.R. Dev. Biol. (2002) [Pubmed]
  9. The JAK/STAT pathway is required for border cell migration during Drosophila oogenesis. Beccari, S., Teixeira, L., Rørth, P. Mech. Dev. (2002) [Pubmed]
  10. GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo. Bach, E.A., Ekas, L.A., Ayala-Camargo, A., Flaherty, M.S., Lee, H., Perrimon, N., Baeg, G.H. Gene Expr. Patterns (2007) [Pubmed]
  11. The Drosophila cytokine receptor Domeless controls border cell migration and epithelial polarization during oogenesis. Ghiglione, C., Devergne, O., Georgenthum, E., Carballès, F., Médioni, C., Cerezo, D., Noselli, S. Development (2002) [Pubmed]
  12. Genetic analysis of contributions of dorsal group and JAK-Stat92E pathway genes to larval hemocyte concentration and the egg encapsulation response in Drosophila. Sorrentino, R.P., Melk, J.P., Govind, S. Genetics (2004) [Pubmed]
  13. Cooperation of JAK/STAT and Notch signaling in the Drosophila foregut. Josten, F., Fuss, B., Feix, M., Meissner, T., Hoch, M. Dev. Biol. (2004) [Pubmed]
  14. Localized JAK/STAT signaling is required for oriented cell rearrangement in a tubular epithelium. Johansen, K.A., Iwaki, D.D., Lengyel, J.A. Development (2003) [Pubmed]
  15. Transcriptional regulation of the Drosophila raf proto-oncogene by Drosophila STAT during development and in immune response. Kwon, E.J., Park, H.S., Kim, Y.S., Oh, E.J., Nishida, Y., Matsukage, A., Yoo, M.A., Yamaguchi, M. J. Biol. Chem. (2000) [Pubmed]
  16. Characterization of two mosquito STATs, AaSTAT and CtSTAT. Differential regulation of tyrosine phosphorylation and DNA binding activity by lipopolysaccharide treatment and by Japanese encephalitis virus infection. Lin, C.C., Chou, C.M., Hsu, Y.L., Lien, J.C., Wang, Y.M., Chen, S.T., Tsai, S.C., Hsiao, P.W., Huang, C.J. J. Biol. Chem. (2004) [Pubmed]
  17. Identification of the first invertebrate interleukin JAK/STAT receptor, the Drosophila gene domeless. Brown, S., Hu, N., Hombría, J.C. Curr. Biol. (2001) [Pubmed]
  18. Notch signaling controls proliferation through cell-autonomous and non-autonomous mechanisms in the Drosophila eye. Reynolds-Kenneally, J., Mlodzik, M. Dev. Biol. (2005) [Pubmed]
  19. JAK/STAT signaling promotes regional specification by negatively regulating wingless expression in Drosophila. Ekas, L.A., Baeg, G.H., Flaherty, M.S., Ayala-Camargo, A., Bach, E.A. Development (2006) [Pubmed]
  20. Cloning and expression of Drosophila SOCS36E and its potential regulation by the JAK/STAT pathway. Karsten, P., Häder, S., Zeidler, M.P. Mech. Dev. (2002) [Pubmed]
  21. Receptor tyrosine kinase signaling and primordial germ cell development. Li, W.X. Cell Cycle (2004) [Pubmed]
  22. Characterisation of Upd2, a Drosophila JAK/STAT pathway ligand. Hombría, J.C., Brown, S., Häder, S., Zeidler, M.P. Dev. Biol. (2005) [Pubmed]
  23. JAK signaling is somatically required for follicle cell differentiation in Drosophila. McGregor, J.R., Xi, R., Harrison, D.A. Development (2002) [Pubmed]
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