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Gene Review:

CCKLR-17D3 - Cholecystokinin-like receptor at 17D3

Drosophila melanogaster

Synonyms: CCKLR-D3, CG32540, CG6861, CG6881, CG6894, ...

Kubiak, T.M. et al.

Kubiak, Larsen, Burton, Bannow, Martin, Zantello, Lowery,

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High impact information on CCKLR-17D3

Cloning and functional expression of the first Drosophila melanogaster sulfakinin receptor DSK-R1 [1].
When expressed in mammalian cells, DSK-R1 was activated by a sulfated, Met(7-->Leu(7)-substituted analog of drosulfakinin-1, FDDY(SO(3)H)GHLRF-NH(2) ([Leu(7)]-DSK-1S) [1].

Other interactions of CCKLR-17D3

The DSK-R1 was specific for the insect sulfakinin since two related vertebrate sulfated peptides, human CCK-8 and gastrin-II, were found inactive when tested at concentrations up to 10(-5) M [1].

References

Cloning and functional expression of the first Drosophila melanogaster sulfakinin receptor DSK-R1. Kubiak, T.M., Larsen, M.J., Burton, K.J., Bannow, C.A., Martin, R.A., Zantello, M.R., Lowery, D.E. Biochem. Biophys. Res. Commun. (2002) [Pubmed]

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