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Gene Review

Sulf1  -  Sulfated

Drosophila melanogaster

Synonyms: CG6725, DSulf, DSulf1, DmSulf-1, Dmel\CG6725, ...
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High impact information on Sulf1


Biological context of Sulf1


Anatomical context of Sulf1


Associations of Sulf1 with chemical compounds

  • After separation of total fly protein by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, proteins with sulfated carbohydrates and proteins containing tyrosine sulfate were found in all the molecular weight ranges analyzed [9].
  • The unsulfated [Leu(7)]-DSK-1 was ca. 3000-fold less potent than its sulfated counterpart which stresses the importance of the sulfate moiety for the biological activity of drosulfakinin [10].

Regulatory relationships of Sulf1

  • When expressed in mammalian cells, DSK-R1 was activated by a sulfated, Met(7-->Leu(7)-substituted analog of drosulfakinin-1, FDDY(SO(3)H)GHLRF-NH(2) ([Leu(7)]-DSK-1S) [10].

Other interactions of Sulf1

  • The DSK-R1 was specific for the insect sulfakinin since two related vertebrate sulfated peptides, human CCK-8 and gastrin-II, were found inactive when tested at concentrations up to 10(-5) M [10].


  1. Order out of chaos: assembly of ligand binding sites in heparan sulfate. Esko, J.D., Selleck, S.B. Annu. Rev. Biochem. (2002) [Pubmed]
  2. Glutactin, a novel Drosophila basement membrane-related glycoprotein with sequence similarity to serine esterases. Olson, P.F., Fessler, L.I., Nelson, R.E., Sterne, R.E., Campbell, A.G., Fessler, J.H. EMBO J. (1990) [Pubmed]
  3. Drosophila pipe protein activity in the ovary and the embryonic salivary gland does not require heparan sulfate glycosaminoglycans. Zhu, X., Sen, J., Stevens, L., Goltz, J.S., Stein, D. Development (2005) [Pubmed]
  4. Identification and characterization of a Drosophila homologue to the vertebrate neuropeptide cholecystokinin. Nichols, R., Schneuwly, S.A., Dixon, J.E. J. Biol. Chem. (1988) [Pubmed]
  5. Expression, tyrosine sulfation, and secretion of yolk protein 2 of Drosophila melanogaster in mouse fibroblasts. Friederich, E., Baeuerle, P.A., Garoff, H., Hovemann, B., Huttner, W.B. J. Biol. Chem. (1988) [Pubmed]
  6. Computational Identification of Ftz/Ftz-F1 downstream target genes. Bowler, T., Kosman, D., Licht, J.D., Pick, L. Dev. Biol. (2006) [Pubmed]
  7. Regulating morphogen gradients in the Drosophila wing. Cadigan, K.M. Semin. Cell Dev. Biol. (2002) [Pubmed]
  8. Papilin: a Drosophila proteoglycan-like sulfated glycoprotein from basement membranes. Campbell, A.G., Fessler, L.I., Salo, T., Fessler, J.H. J. Biol. Chem. (1987) [Pubmed]
  9. Tyrosine sulfation of yolk proteins 1, 2, and 3 in Drosophila melanogaster. Baeuerle, P.A., Huttner, W.B. J. Biol. Chem. (1985) [Pubmed]
  10. Cloning and functional expression of the first Drosophila melanogaster sulfakinin receptor DSK-R1. Kubiak, T.M., Larsen, M.J., Burton, K.J., Bannow, C.A., Martin, R.A., Zantello, M.R., Lowery, D.E. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
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