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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Dop2R  -  Dopamine 2-like receptor

Drosophila melanogaster

Synonyms: CG17004, CG33517, CG9569, D2R, DD2R, ...
 
 
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High impact information on D2R

  • Pharmacologic assessment of three DD2R isoforms, DD2R-606, DD2R-506, and DD2R-461, revealed that among the endogenous biogenic amines, dopamine is most potent at each receptor [1].
  • Eight isoforms of the Drosophila D2-like receptor (DD2R) transcript have been identified, each the result of alternative splicing [1].
  • The same substitutions also converted piribedil and ropinirole, which lacked appreciable activity on the DD2R, to partial agonists [2].
  • A converse triple amino acid substitution of human residues into the fly receptor (DD2R-A133V/S160C/I211L) markedly enhanced pergolide efficacy and potency at the mutant DD2R [2].

References

  1. A Drosophila dopamine 2-like receptor: Molecular characterization and identification of multiple alternatively spliced variants. Hearn, M.G., Ren, Y., McBride, E.W., Reveillaud, I., Beinborn, M., Kopin, A.S. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Identification of amino Acid determinants of dopamine 2 receptor synthetic agonist function. Al-Fulaij, M.A., Ren, Y., Beinborn, M., Kopin, A.S. J. Pharmacol. Exp. Ther. (2007) [Pubmed]
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