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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

cactin  -  CG1676 gene product from transcript CG1676-RB

Drosophila melanogaster

Synonyms: CG1676, Cactin, Cactus-interacting protein, Dmel\CG1676
 
 
 
 
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High impact information on cactin

  • Both the embryonic lethality and ventralization are strongly increased, suggesting that cactin functions in the Rel pathway controlling the formation of dorsal-ventral embryonic polarity [1].
  • Over-expression of cactin in a cactus(A2) heterozygous background results in the enhancement of the cactus phenotype [1].
  • In a two-hybrid screen for additional components of the pathway using the Drosophila I-kappaB protein Cactus as a bait, we isolated a novel coiled-coil protein with N-terminal Arg-Asp (RD)- like motifs that we call Cactin [1].

References

  1. Cactin, a conserved protein that interacts with the Drosophila IkappaB protein cactus and modulates its function. Lin, P., Huang, L.H., Steward, R. Mech. Dev. (2000) [Pubmed]
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