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Gene Review: 

dapC  -  N-succinyldiaminopimelate aminotransferase

Corynebacterium glutamicum ATCC 13032

 
 
 
 
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Disease relevance of dapC

  • Identification and characterization of the last two unknown genes, dapC and dapF, in the succinylase branch of the L-lysine biosynthesis of Corynebacterium glutamicum [1].
 

High impact information on dapC

  • Overexpression of the dapF or the dapC gene in an industrial C. glutamicum strain resulted in an increased L-lysine production, indicating that both genes might be relevant targets for the development of improved production strains [1].
  • Overexpression of the dapC gene in C. glutamicum resulted in a 9-fold increase of the specific aminotransferase activity [1].
  • Even a mutation of the two genes dapC and ddh, interrupting both branches of the split pathway, could be established in C. glutamicum [1].
 

Biological context of dapC

  • The inspection of the complete genome sequence of Corynebacterium glutamicum ATCC 13032 led to the identification of dapC and dapF, the last two unknown genes of the succinylase branch of the L-lysine biosynthesis [1].

References

  1. Identification and characterization of the last two unknown genes, dapC and dapF, in the succinylase branch of the L-lysine biosynthesis of Corynebacterium glutamicum. Hartmann, M., Tauch, A., Eggeling, L., Bathe, B., Möckel, B., Pühler, A., Kalinowski, J. J. Biotechnol. (2003) [Pubmed]
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