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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

tim  -  timeless

Drosophila melanogaster

Synonyms: CG3234, Dmel\CG3234, Protein timeless, Ritsu, TIM, ...
 
 
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Psychiatry related information on tim

  • Introduction of the D. ananassae tim homolog rescued the rhythm of the locomotor activity of about 44% of a population of D. melanogaster tim(01) flies [1].
 

High impact information on tim

  • A third allele, dbtP, causes pupal lethality and eliminates circadian cycling of per and tim gene products in larvae [2].
  • Within these feedback loops, CLK and CYCLE (CYC) activate per and tim transcription at the same time as they repress Clk transcription, thus controlling the opposite cycling phases of these transcripts [3].
  • The N-terminal sequence of vTIM and sequence analysis of genomic DNA from several strains of D. melanogaster suggest that only one of two possible translation initiation sites found in tim mRNA is sufficient to generate circadian rhythms in D. melanogaster [4].
 

Other interactions of tim

  • The Drosophila circadian oscillator consists of interlocked period (per)/timeless (tim) and Clock (Clk) transcriptional/translational feedback loops [3].

References

  1. Highly conserved Drosophila ananassae timeless gene functions as a clock component in Drosophila melanogaster. Nishinokubi, I., Shimoda, M., Kako, K., Sakai, T., Fukamizu, A., Ishida, N. Gene (2003) [Pubmed]
  2. double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation. Price, J.L., Blau, J., Rothenfluh, A., Abodeely, M., Kloss, B., Young, M.W. Cell (1998) [Pubmed]
  3. VRILLE feeds back to control circadian transcription of Clock in the Drosophila circadian oscillator. Glossop, N.R., Houl, J.H., Zheng, H., Ng, F.S., Dudek, S.M., Hardin, P.E. Neuron (2003) [Pubmed]
  4. Comparison of chromosomal DNA composing timeless in Drosophila melanogaster and D. virilis suggests a new conserved structure for the TIMELESS protein. Myers, M.P., Rothenfluh, A., Chang, M., Young, M.W. Nucleic Acids Res. (1997) [Pubmed]
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