The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

tim  -  timeless

Drosophila melanogaster

Synonyms: CG3234, Dmel\CG3234, Protein timeless, Ritsu, TIM, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Psychiatry related information on tim

  • Introduction of the D. ananassae tim homolog rescued the rhythm of the locomotor activity of about 44% of a population of D. melanogaster tim(01) flies [1].

High impact information on tim

  • A third allele, dbtP, causes pupal lethality and eliminates circadian cycling of per and tim gene products in larvae [2].
  • Within these feedback loops, CLK and CYCLE (CYC) activate per and tim transcription at the same time as they repress Clk transcription, thus controlling the opposite cycling phases of these transcripts [3].
  • The N-terminal sequence of vTIM and sequence analysis of genomic DNA from several strains of D. melanogaster suggest that only one of two possible translation initiation sites found in tim mRNA is sufficient to generate circadian rhythms in D. melanogaster [4].

Other interactions of tim

  • The Drosophila circadian oscillator consists of interlocked period (per)/timeless (tim) and Clock (Clk) transcriptional/translational feedback loops [3].


  1. Highly conserved Drosophila ananassae timeless gene functions as a clock component in Drosophila melanogaster. Nishinokubi, I., Shimoda, M., Kako, K., Sakai, T., Fukamizu, A., Ishida, N. Gene (2003) [Pubmed]
  2. double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation. Price, J.L., Blau, J., Rothenfluh, A., Abodeely, M., Kloss, B., Young, M.W. Cell (1998) [Pubmed]
  3. VRILLE feeds back to control circadian transcription of Clock in the Drosophila circadian oscillator. Glossop, N.R., Houl, J.H., Zheng, H., Ng, F.S., Dudek, S.M., Hardin, P.E. Neuron (2003) [Pubmed]
  4. Comparison of chromosomal DNA composing timeless in Drosophila melanogaster and D. virilis suggests a new conserved structure for the TIMELESS protein. Myers, M.P., Rothenfluh, A., Chang, M., Young, M.W. Nucleic Acids Res. (1997) [Pubmed]
WikiGenes - Universities