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MeSH Review

Motor Activity

 
 
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Disease relevance of Motor Activity

 

Psychiatry related information on Motor Activity

 

High impact information on Motor Activity

  • The ECM turnover is influenced by physical activity, and both collagen synthesis and degrading metalloprotease enzymes increase with mechanical loading [11].
  • Tissue-specific overexpression of the glycogen synthase kinase-3 (GSK-3) ortholog shaggy (sgg) shortens the period of the Drosophila circadian locomotor activity cycle [12].
  • Additionally, locomotor activity in light-dark (LD) cycles is impaired and activity levels are reduced in Mop3-/- mice [13].
  • Dopamine also influences initiation and coordination of motor activity and is required for sensorimotor functions [14].
  • Unlike NR1 null mice, these mice survive to adulthood and display behavioral abnormalities, including increased motor activity and stereotypy and deficits in social and sexual interactions [15].
 

Chemical compound and disease context of Motor Activity

 

Biological context of Motor Activity

 

Anatomical context of Motor Activity

 

Gene context of Motor Activity

  • Here we show that mice lacking the Cryl or Cry2 protein display accelerated and delayed free-running periodicity of locomotor activity, respectively [32].
  • Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling [27].
  • Long-term, multielectrode recordings showed that heterozygous Clock mutant neurons have lengthened periods and that homozygous Clock neurons are arrhythmic, paralleling the effects on locomotor activity in the animal [33].
  • Wild-type mice respond to an increase in the fat content of the diet by rapidly increasing diet-induced thermogenesis and by increasing physical activity, neither of which are observed in MC4R-/- mice [34].
  • Mice homozygous for the targeted allele of either mPer1 or mPer2 had severely disrupted locomotor activity rhythms during extended exposure to constant darkness [35].
 

Analytical, diagnostic and therapeutic context of Motor Activity

References

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  2. beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Zheng, H., Jiang, M., Trumbauer, M.E., Sirinathsinghji, D.J., Hopkins, R., Smith, D.W., Heavens, R.P., Dawson, G.R., Boyce, S., Conner, M.W., Stevens, K.A., Slunt, H.H., Sisoda, S.S., Chen, H.Y., Van der Ploeg, L.H. Cell (1995) [Pubmed]
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  15. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Mohn, A.R., Gainetdinov, R.R., Caron, M.G., Koller, B.H. Cell (1999) [Pubmed]
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  21. The effects of norepinephrine transporter inactivation on locomotor activity in mice. Mitchell, H.A., Ahern, T.H., Liles, L.C., Javors, M.A., Weinshenker, D. Biol. Psychiatry (2006) [Pubmed]
  22. Growth hormone replacement therapy in adults with growth hormone deficiency improves maximal oxygen consumption independently of dosing regimen or physical activity. Hartman, M.L., Weltman, A., Zagar, A., Qualy, R.L., Hoffman, A.R., Merriam, G.R. J. Clin. Endocrinol. Metab. (2008) [Pubmed]
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  29. Total energy expenditure and the level of physical activity correlate with plasma leptin concentrations in five-year-old children. Salbe, A.D., Nicolson, M., Ravussin, E. J. Clin. Invest. (1997) [Pubmed]
  30. Effect of somatostatin on gallbladder volume and small intestinal motor activity in humans. Neri, M., Cuccurullo, F., Marzio, L. Gastroenterology (1990) [Pubmed]
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