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Gene Review

rho4  -  Rho family GTPase Rho4

Schizosaccharomyces pombe 972h-

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High impact information on rho4

  • RESULTS: Gene disruption revealed that rho4+ is not essential for cell growth [1].
  • However, rho4-null cells were abnormally elongated and had multiple septa of irregular shape at 37 degrees C. In these cells, F-actin patches were randomly localized all over the cell periphery, and cytoplasmic microtubules (MTs) were misoriented [1].
  • Several lines of evidence indicate that both rho4(+) deletion or rho4(+) overexpression result in a defective cell wall, suggesting an additional role for Rho4 in cell wall integrity [2].


  1. The small GTPase Rho4 is involved in controlling cell morphology and septation in fission yeast. Nakano, K., Mutoh, T., Arai, R., Mabuchi, I. Genes Cells (2003) [Pubmed]
  2. Novel Rho GTPase involved in cytokinesis and cell wall integrity in the fission yeast Schizosaccharomyces pombe. Santos, B., Gutiérrez, J., Calonge, T.M., Pérez, P. Eukaryotic Cell (2003) [Pubmed]
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