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Gene Review

eya  -  eyes absent

Drosophila melanogaster

Synonyms: BcDNA:LD16029, CG9554, CLI, CLIFT, Developmental protein eyes absent, ...
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High impact information on eya

  • Loss- and gain-of-function analyses suggest that the 3' eye enhancer is synergistically activated by a combination of eya, so and dpp signaling, and only indirectly activated by ey, whereas the 5' eye enhancer is primarily regulated by ey, acting in concert with eya and so [1].
  • The transcriptional coactivator eya controls essential cellular functions during organogenesis of Drosophila [2].
  • Ectopic expression of ey can induce the expression of several eye-specification genes (eya, so, and dac) and induce eye formation in multiple locations on the body [3].


  1. Dual regulation and redundant function of two eye-specific enhancers of the Drosophila retinal determination gene dachshund. Pappu, K.S., Ostrin, E.J., Middlebrooks, B.W., Sili, B.T., Chen, R., Atkins, M.R., Gibbs, R., Mardon, G. Development (2005) [Pubmed]
  2. Transcriptional coactivator Drosophila eyes absent homologue 2 is up-regulated in epithelial ovarian cancer and promotes tumor growth. Zhang, L., Yang, N., Huang, J., Buckanovich, R.J., Liang, S., Barchetti, A., Vezzani, C., O'Brien-Jenkins, A., Wang, J., Ward, M.R., Courreges, M.C., Fracchioli, S., Medina, A., Katsaros, D., Weber, B.L., Coukos, G. Cancer Res. (2005) [Pubmed]
  3. Eyeless collaborates with Hedgehog and Decapentaplegic signaling in Drosophila eye induction. Kango-Singh, M., Singh, A., Henry Sun, Y. Dev. Biol. (2003) [Pubmed]
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