Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Pvf2 - PDGF- and VEGF-related factor 2

Drosophila melanogaster

Synonyms: CG13780, DmVEGF-2, Dmel\CG13780, PV2, PVF, ...

Wood, W. et al., Montell, D.J.

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High impact information on Pvf2

In addition, the secreted growth factors called PVFs, previously thought to guide the migrations of hemocytes in the embryo, were found to function instead predominantly as survival factors [1].

Anatomical context of Pvf2

We demonstrate that the migratory patterns of hemocytes at the embryonic ventral midline are orchestrated by chemotactic signals from the PDGF/VEGF ligands Pvf2 and -3 and that these directed migrations occur independently of phosphoinositide 3-kinase (PI3K) signaling [2].

References

The social lives of migrating cells in Drosophila. Montell, D.J. Curr. Opin. Genet. Dev. (2006) [Pubmed]
Distinct mechanisms regulate hemocyte chemotaxis during development and wound healing in Drosophila melanogaster. Wood, W., Faria, C., Jacinto, A. J. Cell Biol. (2006) [Pubmed]

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