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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Hemocytes

 
 
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Disease relevance of Hemocytes

 

High impact information on Hemocytes

  • The VEGF receptor homolog is expressed in hemocytes, and three VEGF homologs are expressed along hemocyte migration routes [6].
  • When wheat germ agglutinin conjugated to fluorescein isothiocyanate is bound to hemocytes from larvae of Drosophila melanogaster, two populations of hemocytes are distinguished [7].
  • Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells [8].
  • For the first time, we are able to examine the roles of Rho-family small GTPases during inflammation in vivo and show that Rac-mediated lamellae are essential for hemocyte motility and Rho signaling is necessary for cells to retract from sites of matrix- and cell-cell contacts [9].
  • By contrast, constitutively active hopscotch and hemipterous give massive activation of lamellocyte formation with little or no increase in total hemocyte numbers [10].
 

Chemical compound and disease context of Hemocytes

  • We initially observed that different stimuli, including LPS, E. coli, RGD, fibronectin and heat shock activate hemocyte ERK [11].
  • A model system consisting of an isolated hemocyte protein (47 KDa), isolated hemocyte tyrosinase, isolated hemocytes, tyrosine, and E. coli was used to obtain these results [12].
  • A previous in vitro study has indicated that four phthalate esters (PAEs) could damage hemocytes and decreases the cellular immunity of prawns [Sung, H.H., Kao, W.Y., Su, Y.J., 2003. Effects and toxicity of phthalate esters to hemocytes of giant freshwater prawn, Macrobranchium rosenbergii. Aquat. Toxicol. 64, 25-37] [13].
  • Uptake of LPS/E. coli/latex beads via distinct signalling pathways in medfly hemocytes: the role of MAP kinases activation and protein secretion [14].
  • Those GTN concentrations that did not have a negative effect on hemocyte viability did not produce sufficient NO to significantly alter the chemiluminescent response to zymosan in all cases, nor the ability of hemocytes to phagocytose bacteria (Escherichia coli) [15].
 

Biological context of Hemocytes

 

Anatomical context of Hemocytes

 

Associations of Hemocytes with chemical compounds

  • We also illustrate how important, evolutionarily conserved, blood-cell-regulatory molecules, such as calcium and glutathione, can be studied functionally within hemocytes [25].
  • The injection of a synthetic analog of [Met]enkephalin [( D-Ala2,Met5]enkephalinamide, DAMA; 10(-6) M) had a stimulatory, naloxone-reversible effect on the directed migration of immunocompetent hemocytes [26].
  • Homologous repeats are found in L-6, a bacterial lipopolysaccharide-binding lectin from horseshoe crab hemocytes [27].
  • Additional serine proteinases expressed in M. sexta hemocytes and fat body have been discovered [28].
  • The hemocytes of the horseshoe crab have been found to contain a new family of Arthropodous antibiotics, termed the "tachyplesin family." These peptides are composed of 17-18 amino acid residues with a carboxyl-terminal arginine alpha-amide [29].
 

Gene context of Hemocytes

  • In contrast, whereas U-shaped and SrpNC together blocked crystal cell production, coexpression of U-shaped with noninteracting Srp proteins failed to prevent overproduction of this hemocyte population [17].
  • Here, we take a gain of function approach to study Drosophila tetraspanin Tsp68C and its effect on larval hemocytes [30].
  • In addition, gcm has a role in the differentiation of the plasmatocyte/macrophage lineage of hemocytes [31].
  • We find that preventing hemocyte migration by removing the function of the Drosophila VEGF receptor homologue, Pvr, or by disrupting Rac1 function in these cells, inhibits condensation [32].
  • This overproduction of hemocytes is attributed to the loss of lwr function primarily in hemocytes and the lymph glands, a hematopoietic organ in Drosophila larvae [33].
 

Analytical, diagnostic and therapeutic context of Hemocytes

References

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  2. Central role of hemocytes in Autographa californica M nucleopolyhedrovirus pathogenesis in Heliothis virescens and Helicoverpa zea. Trudeau, D., Washburn, J.O., Volkman, L.E. J. Virol. (2001) [Pubmed]
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  11. Distinct LPS-induced signals regulate LPS uptake and morphological changes in medfly hemocytes. Soldatos, A.N., Metheniti, A., Mamali, I., Lambropoulou, M., Marmaras, V.J. Insect Biochem. Mol. Biol. (2003) [Pubmed]
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  13. The toxic effect of phthalate esters on immune responses of giant freshwater prawn (Macrobrachium rosenbergii) via oral treatment. Chen, W.L., Sung, H.H. Aquat. Toxicol. (2005) [Pubmed]
  14. Uptake of LPS/E. coli/latex beads via distinct signalling pathways in medfly hemocytes: the role of MAP kinases activation and protein secretion. Lamprou, I., Tsakas, S., Theodorou, G.L., Karakantza, M., Lampropoulou, M., Marmaras, V.J. Biochim. Biophys. Acta (2005) [Pubmed]
  15. Production of nitric oxide by mussel (Mytilus galloprovincialis) hemocytes and effect of exogenous nitric oxide on phagocytic functions. Tafalla, C., Novoa, B., Figueras, A. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2002) [Pubmed]
  16. A serine protease zymogen functions as a pattern-recognition receptor for lipopolysaccharides. Ariki, S., Koori, K., Osaki, T., Motoyama, K., Inamori, K., Kawabata, S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  17. Combinatorial interactions of serpent, lozenge, and U-shaped regulate crystal cell lineage commitment during Drosophila hematopoiesis. Fossett, N., Hyman, K., Gajewski, K., Orkin, S.H., Schulz, R.A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  18. Expression cloning of dSR-CI, a class C macrophage-specific scavenger receptor from Drosophila melanogaster. Pearson, A., Lux, A., Krieger, M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  19. Tiggrin, a novel Drosophila extracellular matrix protein that functions as a ligand for Drosophila alpha PS2 beta PS integrins. Fogerty, F.J., Fessler, L.I., Bunch, T.A., Yaron, Y., Parker, C.G., Nelson, R.E., Brower, D.L., Gullberg, D., Fessler, J.H. Development (1994) [Pubmed]
  20. A role for the Drosophila Toll/Cactus pathway in larval hematopoiesis. Qiu, P., Pan, P.C., Govind, S. Development (1998) [Pubmed]
  21. Tissue-specific ecdysone responses: regulation of the Drosophila genes Eip28/29 and Eip40 during larval development. Andres, A.J., Cherbas, P. Development (1992) [Pubmed]
  22. Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases. Kramerova, I.A., Kawaguchi, N., Fessler, L.I., Nelson, R.E., Chen, Y., Kramerov, A.A., Kusche-Gullberg, M., Kramer, J.M., Ackley, B.D., Sieron, A.L., Prockop, D.J., Fessler, J.H. Development (2000) [Pubmed]
  23. Draper-mediated and phosphatidylserine-independent phagocytosis of apoptotic cells by Drosophila hemocytes/macrophages. Manaka, J., Kuraishi, T., Shiratsuchi, A., Nakai, Y., Higashida, H., Henson, P., Nakanishi, Y. J. Biol. Chem. (2004) [Pubmed]
  24. A lipopolysaccharide- and beta-1,3-glucan-binding protein from hemocytes of the freshwater crayfish Pacifastacus leniusculus. Purification, characterization, and cDNA cloning. Lee, S.Y., Wang, R., Söderhäll, K. J. Biol. Chem. (2000) [Pubmed]
  25. Fluorescence-activated cell sorting (FACS) of Drosophila hemocytes reveals important functional similarities to mammalian leukocytes. Tirouvanziam, R., Davidson, C.J., Lipsick, J.S., Herzenberg, L.A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  26. Evidence for the involvement of opioid neuropeptides in the adherence and migration of immunocompetent invertebrate hemocytes. Stefano, G.B., Leung, M.K., Zhao, X.H., Scharrer, B. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  27. Cloning and characterization of Physarum polycephalum tectonins. Homologues of Limulus lectin L-6. Huh, C.G., Aldrich, J., Mottahedeh, J., Kwon, H., Johnson, C., Marsh, R. J. Biol. Chem. (1998) [Pubmed]
  28. Innate immune responses of a lepidopteran insect, Manduca sexta. Kanost, M.R., Jiang, H., Yu, X.Q. Immunol. Rev. (2004) [Pubmed]
  29. Antimicrobial tachyplesin peptide precursor. cDNA cloning and cellular localization in the horseshoe crab (Tachypleus tridentatus). Shigenaga, T., Muta, T., Toh, Y., Tokunaga, F., Iwanaga, S. J. Biol. Chem. (1990) [Pubmed]
  30. Increased expression of Drosophila tetraspanin, Tsp68C, suppresses the abnormal proliferation of ytr-deficient and Ras/Raf-activated hemocytes. Sinenko, S.A., Mathey-Prevot, B. Oncogene (2004) [Pubmed]
  31. gcm2 promotes glial cell differentiation and is required with glial cells missing for macrophage development in Drosophila. Alfonso, T.B., Jones, B.W. Dev. Biol. (2002) [Pubmed]
  32. Condensation of the central nervous system in embryonic Drosophila is inhibited by blocking hemocyte migration or neural activity. Olofsson, B., Page, D.T. Dev. Biol. (2005) [Pubmed]
  33. The lesswright mutation activates Rel-related proteins, leading to overproduction of larval hemocytes in Drosophila melanogaster. Huang, L., Ohsako, S., Tanda, S. Dev. Biol. (2005) [Pubmed]
  34. Isolation, purification, and amino acid composition of the tunicate hemocyte Thy-1 homolog. Mansour, M.H., DeLange, R., Cooper, E.L. J. Biol. Chem. (1985) [Pubmed]
  35. Mortalin-Based Cytoplasmic Sequestration of p53 in a Nonmammalian Cancer Model. Walker, C., Böttger, S., Low, B. Am. J. Pathol. (2006) [Pubmed]
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