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Gene Review

GlcAT-S  -  CG3881 gene product from transcript CG3881-RA

Drosophila melanogaster

Synonyms: Beta-1,3-glucuronyltransferase S, CG3881, DGlcAT-S, DmGlcAT-BSI, Dmel\CG3881, ...
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High impact information on GlcAT-S

  • The genes encode active enzymes, which we have designated DmGlcAT-I, DmGlcAT-BSI, and DmGlcAT-BSII (where BS stands for "broad specificity") [1].
  • Galbeta1-3GlcNAc and Galbeta1-3GalNAc, disaccharide structures widely found in N- and O-glycans of glycoproteins and glycolipids, also serve as acceptors for DmGlcAT-BSI and -BSII [1].
  • Strikingly, DmGlcAT-I has specificity for Galbeta1-3Galbeta1-4Xyl, whereas DmGlcAT-BSI and DmGlcAT-BSII act on a wide array of substrates with non-reducing terminal beta1,3- and beta1,4-linked Gal residues [1].


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