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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GlcAT-S  -  CG3881 gene product from transcript CG3881-RA

Drosophila melanogaster

Synonyms: Beta-1,3-glucuronyltransferase S, CG3881, DGlcAT-S, DmGlcAT-BSI, Dmel\CG3881, ...
 
 
 
 
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High impact information on GlcAT-S

  • The genes encode active enzymes, which we have designated DmGlcAT-I, DmGlcAT-BSI, and DmGlcAT-BSII (where BS stands for "broad specificity") [1].
  • Galbeta1-3GlcNAc and Galbeta1-3GalNAc, disaccharide structures widely found in N- and O-glycans of glycoproteins and glycolipids, also serve as acceptors for DmGlcAT-BSI and -BSII [1].
  • Strikingly, DmGlcAT-I has specificity for Galbeta1-3Galbeta1-4Xyl, whereas DmGlcAT-BSI and DmGlcAT-BSII act on a wide array of substrates with non-reducing terminal beta1,3- and beta1,4-linked Gal residues [1].

References

  1. Identification and characterization of three Drosophila melanogaster glucuronyltransferases responsible for the synthesis of the conserved glycosaminoglycan-protein linkage region of proteoglycans. Two novel homologs exhibit broad specificity toward oligosaccharides from proteoglycans, glycoproteins, and glycosphingolipids. Kim, B.T., Tsuchida, K., Lincecum, J., Kitagawa, H., Bernfield, M., Sugahara, K. J. Biol. Chem. (2003) [Pubmed]
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