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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

IP3K1  -  Inositol 1,4,5-triphosphate kinase 1

Drosophila melanogaster

Synonyms: CG4026, D-IP3K1, Dmel\CG4026, IP3KI, IP[[3]]K-1, ...
 
 
 
 
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High impact information on IP3K1

  • We show here that ubiquitous overexpression of D-IP3K1 confers resistance of flies to H(2)O(2)- but not to paraquat-induced oxidative stress [1].
  • Additional genetic analysis with other members of IP3 and IP4 signaling pathways led us to propose that the D-IP3K1 protective effect is mainly mediated through the reduction of IP3 level (which probably results in reduced Ca(2+) release from internal stores), rather than through the rise of IP4 level [1].

References

  1. Control of oxidative stress resistance by IP3 kinase in Drosophila melanogaster. Monnier, V., Girardot, F., Audin, W., Tricoire, H. Free Radic. Biol. Med. (2002) [Pubmed]
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