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Chemical Compound Review

Superoxol     hydrogen peroxide

Synonyms: Inhibine, Metrokur, Mirasept, Oxigenal, perhydrol, ...
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Disease relevance of hydrogen peroxide


Psychiatry related information on hydrogen peroxide


High impact information on hydrogen peroxide


Chemical compound and disease context of hydrogen peroxide


Biological context of hydrogen peroxide


Anatomical context of hydrogen peroxide


Associations of hydrogen peroxide with other chemical compounds


Gene context of hydrogen peroxide

  • Here we present genetic and biochemical evidence for the requirement of Rad1-Rad10 nuclease in the removal of 3'-blocked termini from DNA strand breaks induced on treatment of yeast cells with the oxidative DNA damaging agent H(2)O(2) [33].
  • HDL-associated PON, as well as purified PON, were also able to substantially hydrolyze (up to 25%) hydrogen peroxide (H2O2), a major reactive oxygen species produced under oxidative stress during atherogenesis [34].
  • The interaction between PP5 and ASK1 was induced by H(2)O(2) treatment and was followed by the decrease in ASK1 activity [35].
  • Furthermore, H(2)O(2-) or UV-stimulated SAPK activity was higher in mouse embryonic fibroblast (MEF) cells from PS1-null mice than in MEF cells from PS(+/+) mice [36].
  • In addition, the redox states of both ATGPX3 and ABI2 were found to be regulated by H(2)O(2) [37].

Analytical, diagnostic and therapeutic context of hydrogen peroxide


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  15. NPS6, Encoding a Nonribosomal Peptide Synthetase Involved in Siderophore-Mediated Iron Metabolism, Is a Conserved Virulence Determinant of Plant Pathogenic Ascomycetes. Oide, S., Moeder, W., Krasnoff, S., Gibson, D., Haas, H., Yoshioka, K., Turgeon, B.G. Plant Cell (2006) [Pubmed]
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  18. Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis. Jiang, H., Ren, Y., Zhao, J., Feng, J. Hum. Mol. Genet. (2004) [Pubmed]
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  20. Myoglobin function in exercising skeletal muscle. Cole, R.P. Science (1982) [Pubmed]
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  22. Complex cellular responses to reactive oxygen species. Temple, M.D., Perrone, G.G., Dawes, I.W. Trends Cell Biol. (2005) [Pubmed]
  23. Therapeutic effects of lysophosphatidylcholine in experimental sepsis. Yan, J.J., Jung, J.S., Lee, J.E., Lee, J., Huh, S.O., Kim, H.S., Jung, K.C., Cho, J.Y., Nam, J.S., Suh, H.W., Kim, Y.H., Song, D.K. Nat. Med. (2004) [Pubmed]
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  31. Generation of hydroperoxides in isolated rat hepatocytes and hepatic mitochondria exposed to hydrophobic bile acids. Sokol, R.J., Winklhofer-Roob, B.M., Devereaux, M.W., McKim, J.M. Gastroenterology (1995) [Pubmed]
  32. p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation. Takekawa, M., Adachi, M., Nakahata, A., Nakayama, I., Itoh, F., Tsukuda, H., Taya, Y., Imai, K. EMBO J. (2000) [Pubmed]
  33. Requirement of yeast Rad1-Rad10 nuclease for the removal of 3'-blocked termini from DNA strand breaks induced by reactive oxygen species. Guzder, S.N., Torres-Ramos, C., Johnson, R.E., Haracska, L., Prakash, L., Prakash, S. Genes Dev. (2004) [Pubmed]
  34. Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase. Aviram, M., Rosenblat, M., Bisgaier, C.L., Newton, R.S., Primo-Parmo, S.L., La Du, B.N. J. Clin. Invest. (1998) [Pubmed]
  35. Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress. Morita, K., Saitoh, M., Tobiume, K., Matsuura, H., Enomoto, S., Nishitoh, H., Ichijo, H. EMBO J. (2001) [Pubmed]
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  37. An Arabidopsis glutathione peroxidase functions as both a redox transducer and a scavenger in abscisic Acid and drought stress responses. Miao, Y., Lv, D., Wang, P., Wang, X.C., Chen, J., Miao, C., Song, C.P. Plant Cell (2006) [Pubmed]
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