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Gene Review

Sps2  -  Selenophosphate synthetase 2

Drosophila melanogaster

Synonyms: CG5025, Dmel\CG5025, Dsps2, SPS2, Selenide, water dikinase 2, ...
 
 
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High impact information on Sps2

  • This computational screen and subsequent metabolic labeling with (75)Se and characterization of selenoprotein mRNA expression resulted in identification of three selenoproteins: selenophosphate synthetase 2 and novel G-rich and BthD selenoproteins that had no homology to known proteins [1].
  • The open reading frame of Dsps2 mRNA is interrupted by an UGA stop codon [2].

References

  1. Selenium metabolism in Drosophila: selenoproteins, selenoprotein mRNA expression, fertility, and mortality. Martin-Romero, F.J., Kryukov, G.V., Lobanov, A.V., Carlson, B.A., Lee, B.J., Gladyshev, V.N., Hatfield, D.L. J. Biol. Chem. (2001) [Pubmed]
  2. The class 2 selenophosphate synthetase gene of Drosophila contains a functional mammalian-type SECIS. Hirosawa-Takamori, M., Jäckle, H., Vorbrüggen, G. EMBO Rep. (2000) [Pubmed]
 
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