Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

BthD - BthD selenoprotein

Drosophila melanogaster

Synonyms: CG11177, Dmel\CG11177, SelH, Selenoprotein BthD, dSelH, ...

Kwon, S.Y. et al., Martin-Romero, F.J. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on BthD

We found that loss of BthD compromised salivary gland morphogenesis and reduced animal viability [1].
To elucidate the function of BthD and the role of selenoproteins in cellular metabolism and health, we analyzed the developmental expression profile of this protein and used inducible RNA interference (RNAi) to ablate function [1].
We find that BthD is dynamically expressed during Drosophila development. bthD mRNA and protein are abundant in the ovaries of female flies and are deposited into the developing oocyte [1].
At later stages of embryogenesis, BthD is expressed highly in the developing salivary gland [1].
This computational screen and subsequent metabolic labeling with (75)Se and characterization of selenoprotein mRNA expression resulted in identification of three selenoproteins: selenophosphate synthetase 2 and novel G-rich and BthD selenoproteins that had no homology to known proteins [2].

Anatomical context of BthD

The Drosophila selenoprotein BthD is required for survival and has a role in salivary gland development [1].

References

The Drosophila selenoprotein BthD is required for survival and has a role in salivary gland development. Kwon, S.Y., Badenhorst, P., Martin-Romero, F.J., Carlson, B.A., Paterson, B.M., Gladyshev, V.N., Lee, B.J., Hatfield, D.L. Mol. Cell. Biol. (2003) [Pubmed]
Selenium metabolism in Drosophila: selenoproteins, selenoprotein mRNA expression, fertility, and mortality. Martin-Romero, F.J., Kryukov, G.V., Lobanov, A.V., Carlson, B.A., Lee, B.J., Gladyshev, V.N., Hatfield, D.L. J. Biol. Chem. (2001) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.