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Gene Review

hcnA  -  hydrogen cyanide synthase HcnA

Pseudomonas protegens Pf-5

 
 
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High impact information on hcnA

  • Overexpression of rsmY restored the expression of target genes (hcnA, aprA) to gacS or gacA mutants [1].
  • Single null mutations in either rsmA or rsmE resulted in a slight increase in the expression of hcnA, aprA, and phlA [2].
  • Overexpression of rsmZ effectively suppressed the negative effect of gacS and gacA mutations on target genes, i.e., hcnA (for hydrogen cyanide synthase) and aprA (for the major exoprotease) [3].
  • The hcnA promoter was mapped by primer extension; the -40 sequence (TTGGC ... ATCAA) resembled the consensus FNR (fumarate and nitrate reductase regulator) binding sequence (TTGAT ... ATCAA) [4].
  • By contrast, the rpoS mutant showed a slight increase in the expression of the hcnA (HCN synthase subunit) gene and of the aprA (major exoprotease) gene, whereas overexpression of sigmaS strongly reduced the expression of these genes [5].
 

Associations of hcnA with chemical compounds

  • Overexpression of rsmE strongly reduced the expression of target genes (hcnA, for a hydrogen cyanide synthase subunit; aprA, for the main exoprotease; and phlA, for a component of 2,4-diacetylphloroglucinol biosynthesis) [2].

References

 
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