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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Agap1  -  ArfGAP with GTPase domain, ankyrin repeat...

Mus musculus

Synonyms: AGAP-1, Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1, Centaurin-gamma-2, Centg2, Cnt-g2, ...
 
 
 
 
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High impact information on Centg2

  • Compared to wild-type Arf1, Arf1 with the amino terminal 13 ([Delta13]Arf1) and 17 amino acids ([Delta17]Arf1) deleted had 200- and 4000-fold reduced interaction with ASAP1 and 150-fold reduced interaction with AGAP1 [1].
  • Leucine 8 contributed to the interaction with Arf GAP1 but not with ASAP1 and AGAP1 [1].
 

Other interactions of Centg2

  • Amino acids 2-17 of Arf1, isolated from the protein, inhibited GAP activity of Arf GAP1, ASAP1 and AGAP1 and bound directly to ASAP1 [1].

References

  1. Differences between AGAP1, ASAP1 and Arf GAP1 in substrate recognition: interaction with the N-terminus of Arf1. Yoon, H.Y., Jacques, K., Nealon, B., Stauffer, S., Premont, R.T., Randazzo, P.A. Cell. Signal. (2004) [Pubmed]
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