Chemical Compound Review:
leucine (2R)-2-amino-4-methyl- pentanoic acid
Synonyms:
D-Leucin, D-Leuzin, D-LEUCINE, D-Leu, D-Homo-valine, ...
- A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA. Kadowaki, T., Kadowaki, H., Mori, Y., Tobe, K., Sakuta, R., Suzuki, Y., Tanabe, Y., Sakura, H., Awata, T., Goto, Y. N. Engl. J. Med. (1994)
- The complete form of X-linked congenital stationary night blindness is caused by mutations in a gene encoding a leucine-rich repeat protein. Pusch, C.M., Zeitz, C., Brandau, O., Pesch, K., Achatz, H., Feil, S., Scharfe, C., Maurer, J., Jacobi, F.K., Pinckers, A., Andreasson, S., Hardcastle, A., Wissinger, B., Berger, W., Meindl, A. Nat. Genet. (2000)
- Reduced maximal levels of derepression of the isoleucine-valine and leucine enzymes in hisT mutants of Salmonella typhimurium. Bresalier, R.S., Rizzino, A.A., Freundlich, M. Nature (1975)
- Recognition of bZIP proteins by the human T-cell leukaemia virus transactivator Tax. Perini, G., Wagner, S., Green, M.R. Nature (1995)
- Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Hugot, J.P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C.A., Gassull, M., Binder, V., Finkel, Y., Cortot, A., Modigliani, R., Laurent-Puig, P., Gower-Rousseau, C., Macry, J., Colombel, J.F., Sahbatou, M., Thomas, G. Nature (2001)
- Creutzfeldt-Jakob disease patients with congophilic kuru plaques have the missense variant prion protein common to Gerstmann-Sträussler syndrome. Doh-ura, K., Tateishi, J., Kitamoto, T., Sasaki, H., Sakaki, Y. Ann. Neurol. (1990)
- From genotype to phenotype: a clinical pathological, and biochemical investigation of frontotemporal dementia and parkinsonism (FTDP-17) caused by the P301L tau mutation. Nasreddine, Z.S., Loginov, M., Clark, L.N., Lamarche, J., Miller, B.L., Lamontagne, A., Zhukareva, V., Lee, V.M., Wilhelmsen, K.C., Geschwind, D.H. Ann. Neurol. (1999)
- Autopsy-confirmed familial early-onset Alzheimer disease caused by the l153V presenilin 1 mutation. Janssen, J.C., Lantos, P.L., Fox, N.C., Harvey, R.J., Beck, J., Dickinson, A., Campbell, T.A., Collinge, J., Hanger, D.P., Cipolotti, L., Stevens, J.M., Rossor, M.N. Arch. Neurol. (2001)
- Plasma amino acid levels in Huntington's chorea. Watt, J.A., Cunningham, W.L. The British journal of psychiatry : the journal of mental science. (1978)
- The brain-specific protein MLC1 implicated in megalencephalic leukoencephalopathy with subcortical cysts is expressed in glial cells in the murine brain. Schmitt, A., Gofferje, V., Weber, M., Meyer, J., Mössner, R., Lesch, K.P. Glia (2003)
- Lipopolysaccharide endotoxins. Raetz, C.R., Whitfield, C. Annu. Rev. Biochem. (2002)
- An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Zhang, X., Gureasko, J., Shen, K., Cole, P.A., Kuriyan, J. Cell (2006)
- The evolution of adaptive immune systems. Cooper, M.D., Alder, M.N. Cell (2006)
- Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development. Nakata, K., Abrams, B., Grill, B., Goncharov, A., Huang, X., Chisholm, A.D., Jin, Y. Cell (2005)
- Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features. Kalachikov, S., Evgrafov, O., Ross, B., Winawer, M., Barker-Cummings, C., Martinelli Boneschi, F., Choi, C., Morozov, P., Das, K., Teplitskaya, E., Yu, A., Cayanis, E., Penchaszadeh, G., Kottmann, A.H., Pedley, T.A., Hauser, W.A., Ottman, R., Gilliam, T.C. Nat. Genet. (2002)
- Linkage of a prion protein missense variant to Gerstmann-Sträussler syndrome. Hsiao, K., Baker, H.F., Crow, T.J., Poulter, M., Owen, F., Terwilliger, J.D., Westaway, D., Ott, J., Prusiner, S.B. Nature (1989)
- Ratio of plasma alpha amino-n-butyric acid to leucine as an empirical marker of alcoholism: diagnostic value. Morgan, M.Y., Milsom, J.P., Sherlock, S. Science (1977)
- Defective suppression by insulin of leucine-carbon appearance and oxidation in type 1, insulin-dependent diabetes mellitus. Evidence for insulin resistance involving glucose and amino acid metabolism. Tessari, P., Nosadini, R., Trevisan, R., De Kreutzenberg, S.V., Inchiostro, S., Duner, E., Biolo, G., Marescotti, M.C., Tiengo, A., Crepaldi, G. J. Clin. Invest. (1986)
- Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle. Biolo, G., Declan Fleming, R.Y., Wolfe, R.R. J. Clin. Invest. (1995)
- Point mutation in a leucine-rich repeat of platelet glycoprotein Ib alpha resulting in the Bernard-Soulier syndrome. Ware, J., Russell, S.R., Marchese, P., Murata, M., Mazzucato, M., De Marco, L., Ruggeri, Z.M. J. Clin. Invest. (1993)
- Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain. Benson, M.D., Liepnieks, J., Uemichi, T., Wheeler, G., Correa, R. Nat. Genet. (1993)
- A major developmental transition in early Xenopus embryos: II. Control of the onset of transcription. Newport, J., Kirschner, M. Cell (1982)
- Isolation of a novel gene mutated in Wiskott-Aldrich syndrome. Derry, J.M., Ochs, H.D., Francke, U. Cell (1994)
- Nucleotide sequence of yeast LEU2 shows 5'-noncoding region has sequences cognate to leucine. Andreadis, A., Hsu, Y.P., Kohlhaw, G.B., Schimmel, P. Cell (1982)
- Inhibition of glucose transport into rat islet cells by immunoglobulins from patients with new-onset insulin-dependent diabetes mellitus. Johnson, J.H., Crider, B.P., McCorkle, K., Alford, M., Unger, R.H. N. Engl. J. Med. (1990)
- A single base substitution in 16S ribosomal RNA suppresses streptomycin dependence and increases the frequency of translational errors. Allen, P.N., Noller, H.F. Cell (1991)
- Connectin: a homophilic cell adhesion molecule expressed on a subset of muscles and the motoneurons that innervate them in Drosophila. Nose, A., Mahajan, V.B., Goodman, C.S. Cell (1992)
- A point mutation in the extracellular domain of the human CSF-1 receptor (c-fms proto-oncogene product) activates its transforming potential. Roussel, M.F., Downing, J.R., Rettenmier, C.W., Sherr, C.J. Cell (1988)
- Recognition and signaling by toll-like receptors. West, A.P., Koblansky, A.A., Ghosh, S. Annu. Rev. Cell Dev. Biol. (2006)
- Glycoprotein synthesis and inhibition of glycosylation by tunicamycin in preimplantation mouse embryos: compaction and trophoblast adhesion. Surani, M.A. Cell (1979)
- A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations. Cawthon, R.M., Weiss, R., Xu, G.F., Viskochil, D., Culver, M., Stevens, J., Robertson, M., Dunn, D., Gesteland, R., O'Connell, P. Cell (1990)
- Mutations in the alpha 1 subunit of the inhibitory glycine receptor cause the dominant neurologic disorder, hyperekplexia. Shiang, R., Ryan, S.G., Zhu, Y.Z., Hahn, A.F., O'Connell, P., Wasmuth, J.J. Nat. Genet. (1993)
- Recovery of S. cerevisiae a cells from G1 arrest by alpha factor pheromone requires endopeptidase action. Ciejek, E., Thorner, J. Cell (1979)
- Continuous protein synthesis is required to maintain the probability of entry into S phase. Brooks, R.F. Cell (1977)
- The A. thaliana disease resistance gene RPS2 encodes a protein containing a nucleotide-binding site and leucine-rich repeats. Mindrinos, M., Katagiri, F., Yu, G.L., Ausubel, F.M. Cell (1994)
- tRNA gene transcription in yeast: effects of specified base substitutions in the intragenic promoter. Newman, A.J., Ogden, R.C., Abelson, J. Cell (1983)
- Identification and cloning of a negative regulator of systemic acquired resistance, SNI1, through a screen for suppressors of npr1-1. Li, X., Zhang, Y., Clarke, J.D., Li, Y., Dong, X. Cell (1999)
- Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Bilder, D., Perrimon, N. Nature (2000)
- A giant nucleopore protein that binds Ran/TC4. Yokoyama, N., Hayashi, N., Seki, T., Panté, N., Ohba, T., Nishii, K., Kuma, K., Hayashida, T., Miyata, T., Aebi, U. Nature (1995)
- Organization and structure of an E. coli tRNA operon containing seven tRNA genes. Nakajima, N., Ozeki, H., Shimura, Y. Cell (1981)
- Characterization of ribosomal frameshifting in HIV-1 gag-pol expression. Jacks, T., Power, M.D., Masiarz, F.R., Luciw, P.A., Barr, P.J., Varmus, H.E. Nature (1988)
- Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain. Ferré-D'Amaré, A.R., Prendergast, G.C., Ziff, E.B., Burley, S.K. Nature (1993)
- Placental luteinizing hormone-releasing factor and its synthesis. Khodr, G.S., Siler-Khodr, T.M. Science (1980)
- Effects of low dose oral contraceptives on very low density and low density lipoprotein metabolism. Walsh, B.W., Sacks, F.M. J. Clin. Invest. (1993)