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Gene Review:

gyrA - DNA gyrase subunit A

Staphylococcus haemolyticus JCSC1435

Dubin, D.T. et al., Yonezawa, M. et al.

Dubin, Fitzgibbon, Nahvi, John,

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Disease relevance of gyrA

DNA gyrase gyrA mutations in quinolone-resistant clinical isolates of Staphylococcus haemolyticus [1].

High impact information on gyrA

As for S. aureus, ciprofloxacin resistance (MIC, >/=8 microg/ml) and increased trovafloxacin MICs (0.25 to 2 microg/ml) could be conferred by the combined presence of single mutations in each gyrA and grlA gene [2].

References

DNA gyrase gyrA mutations in quinolone-resistant clinical isolates of Staphylococcus haemolyticus. Yonezawa, M., Takahata, M., Banzawa-Futakuchi, N., Matsubara, N., Watanabe, Y., Narita, H., Matsunaga, T., Igarashi, H., Kawahara, M., Onodera, S. Antimicrob. Agents Chemother. (1996) [Pubmed]
Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin. Dubin, D.T., Fitzgibbon, J.E., Nahvi, M.D., John, J.F. Antimicrob. Agents Chemother. (1999) [Pubmed]

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