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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

brat  -  brain tumor

Drosophila melanogaster

Synonyms: BRAT, Brain tumor protein, Brat, CG10719, Cf, ...
 
 
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High impact information on brat

  • Based on the structure and genetic experiments, we identify putative interaction surfaces for hunchback mRNA and the cofactors Nanos and Brain Tumor. This analysis suggests that similar features in helical repeat proteins are used to bind extended peptides and RNA [1].
  • The distribution of side chains on the inner and outer faces of this half doughnut suggests that the inner face of the PUM-HD binds RNA while the outer face interacts with proteins such as Nanos, Brain Tumor, and cytoplasmic polyadenylation element binding protein [2].
  • Here, we report that the Brain tumor (Brat) translation repressor is partitioned into GMCs via direct interaction with the Miranda scaffolding protein [3].

References

  1. Structure of Pumilio reveals similarity between RNA and peptide binding motifs. Edwards, T.A., Pyle, S.E., Wharton, R.P., Aggarwal, A.K. Cell (2001) [Pubmed]
  2. Crystal structure of a Pumilio homology domain. Wang, X., Zamore, P.D., Hall, T.M. Mol. Cell (2001) [Pubmed]
  3. Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal. Lee, C.Y., Wilkinson, B.D., Siegrist, S.E., Wharton, R.P., Doe, C.Q. Dev. Cell (2006) [Pubmed]
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