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Gene Review

mira  -  miranda

Drosophila melanogaster

Synonyms: CG12249, Dmel\CG12249, MIR, MIRA, Mir, ...
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Disease relevance of mira


High impact information on mira

  • Like Prospero, Brat binds and cosegregates with the adaptor protein Miranda [3].
  • To distinguish between these models, I investigated patterns of nucleotide variability along 37 kb of the recently formed neo-Y chromosome in Drosophila miranda [4].
  • Evidence that positive selection drives Y-chromosome degeneration in Drosophila miranda [4].
  • Here, I compare patterns of genome evolution in a 40-kb gene-rich region on homologous neo-sex chromosomes of Drosophila miranda [5].
  • The asymmetric localization of Miranda protein requires inscuteable [6].

Biological context of mira


Anatomical context of mira


Associations of mira with chemical compounds

  • However, the other apical components, Bazooka-atypical PKC-Par6-Inscuteable, still remain polarized and responsible for asymmetric Miranda localization, suggesting their dominant role in localizing cell-fate determinants [14].
  • Dosage compensation and dietary glucose repression of larval amylase activity in Drosophila miranda [15].

Co-localisations of mira

  • In this study, we show that Miranda is colocalized with Staufen and Prospero in neuroblasts, and is required for the asymmetric cortical localization of both proteins [7].

Other interactions of mira


Analytical, diagnostic and therapeutic context of mira

  • Immunofluorescence on syncytial Drosophila embryos shows that Miranda has a dynamic redistribution and is associated with centrosomes [12].
  • Cellular autoradiography was used to measure relative rates of chromosomal RNA synthesis and to examine the regulatory phenomenon of X-linked dosage compensation in Drosophila miranda, a species containing two distinct, nonhomologous X chromosomes (X1 and X2) [19].
  • We also used in situ hybridization to analyze the neo-Y chromosome of Drosophila miranda, an ancestral autosome that has become attached to the Y chromosome and is now partially heterochromatic [20].
  • PCR analysis was conducted to investigate the frequency of spock and worf and of the previously identified transposons, TRIM and TRAM, at individual chromosomal sites among 12 strains of D. miranda [21].


  1. Preferential Y chromosomal location of TRIM, a novel transposable element of Drosophila miranda, obscura group. Steinemann, M., Steinemann, S. Chromosoma (1991) [Pubmed]
  2. Analysis of chromosomal homologies between two species of the subgenus Sophophora: D. miranda and D. melanogaster using cloned DNA segments. Steinemann, M. Chromosoma (1982) [Pubmed]
  3. Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Betschinger, J., Mechtler, K., Knoblich, J.A. Cell (2006) [Pubmed]
  4. Evidence that positive selection drives Y-chromosome degeneration in Drosophila miranda. Bachtrog, D. Nat. Genet. (2004) [Pubmed]
  5. Adaptation shapes patterns of genome evolution on sexual and asexual chromosomes in Drosophila. Bachtrog, D. Nat. Genet. (2003) [Pubmed]
  6. Miranda is required for the asymmetric localization of Prospero during mitosis in Drosophila. Shen, C.P., Jan, L.Y., Jan, Y.N. Cell (1997) [Pubmed]
  7. Identification of Miranda protein domains regulating asymmetric cortical localization, cargo binding, and cortical release. Fuerstenberg, S., Peng, C.Y., Alvarez-Ortiz, P., Hor, T., Doe, C.Q. Mol. Cell. Neurosci. (1998) [Pubmed]
  8. Asymmetric cell division: Miranda chauffeured by Jaguar? Tuxworth, R., Chia, W. Mol. Cell (2003) [Pubmed]
  9. A protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in Drosophila. Schaefer, M., Shevchenko, A., Shevchenko, A., Knoblich, J.A. Curr. Biol. (2000) [Pubmed]
  10. Mechanisms of asymmetric cell division during animal development. Knoblich, J.A. Curr. Opin. Cell Biol. (1997) [Pubmed]
  11. Miranda as a multidomain adapter linking apically localized Inscuteable and basally localized Staufen and Prospero during asymmetric cell division in Drosophila. Shen, C.P., Knoblich, J.A., Chan, Y.M., Jiang, M.M., Jan, L.Y., Jan, Y.N. Genes Dev. (1998) [Pubmed]
  12. Miranda, a protein involved in neuroblast asymmetric division, is associated with embryonic centrosomes of Drosophila melanogaster. Mollinari, C., Lange, B., González, C. Biol. Cell (2002) [Pubmed]
  13. A 3.5-kb DNA fragment contains the cis-regulatory elements for retina-specific expression and partial dosage compensation of the Arrestin B (ArrB) gene of Drosophila miranda. Krishnan, R., Ganguly, R. Gene (1995) [Pubmed]
  14. Differential functions of G protein and Baz-aPKC signaling pathways in Drosophila neuroblast asymmetric division. Izumi, Y., Ohta, N., Itoh-Furuya, A., Fuse, N., Matsuzaki, F. J. Cell Biol. (2004) [Pubmed]
  15. Dosage compensation and dietary glucose repression of larval amylase activity in Drosophila miranda. Norman, R.A., Doane, W.W. Biochem. Genet. (1990) [Pubmed]
  16. The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts. Petritsch, C., Tavosanis, G., Turck, C.W., Jan, L.Y., Jan, Y.N. Dev. Cell (2003) [Pubmed]
  17. DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila. Petronczki, M., Knoblich, J.A. Nat. Cell Biol. (2001) [Pubmed]
  18. Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal. Lee, C.Y., Wilkinson, B.D., Siegrist, S.E., Wharton, R.P., Doe, C.Q. Dev. Cell (2006) [Pubmed]
  19. Incomplete dosage compensation in an evolving Drosophila sex chromosome. Strobel, E., Pelling, C., Arnheim, N. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  20. Nonrandom distribution of long mono- and dinucleotide repeats in Drosophila chromosomes: correlations with dosage compensation, heterochromatin, and recombination. Lowenhaupt, K., Rich, A., Pardue, M.L. Mol. Cell. Biol. (1989) [Pubmed]
  21. Accumulation of Spock and Worf, two novel non-LTR retrotransposons, on the neo-Y chromosome of Drosophila miranda. Bachtrog, D. Mol. Biol. Evol. (2003) [Pubmed]
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