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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ubc-9  -  Protein UBC-9

Caenorhabditis elegans

 
 
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Disease relevance of ubc-9

  • The LIN-35 retinoblastoma protein homolog and the ubiquitin-conjugating enzyme UBC-18 function redundantly to control an early step of pharyngeal morphogenesis in C. elegans [1].
 

High impact information on ubc-9

  • Furthermore, depletion of ubc-9 and tac-1 leads to radiation sensitivity and a high incidence of males, respectively, potentially linking these genes to the C. elegans BRCA1 pathway [2].

References

  1. ARI-1, an RBR family ubiquitin-ligase, functions with UBC-18 to regulate pharyngeal development in C. elegans. Qiu, X., Fay, D.S. Dev. Biol. (2006) [Pubmed]
  2. BRCA1/BARD1 orthologs required for DNA repair in Caenorhabditis elegans. Boulton, S.J., Martin, J.S., Polanowska, J., Hill, D.E., Gartner, A., Vidal, M. Curr. Biol. (2004) [Pubmed]
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