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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

U2A  -  CG1406 gene product from transcript CG1406-RA

Drosophila melanogaster

Synonyms: BcDNA:RE56869, CG1406, Dmel\CG1406, U2 snRNP A', U2A', ...
 
 
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High impact information on U2A

  • The concave surface of a parallel beta-sheet within the leucine-rich-repeat region of U2A' interacts with the ribonucleoprotein domain of U2B" on the surface opposite its RNA-binding surface [1].
  • Here we show that Drosophila U2A' protein interacts with SNF in vivo and, like its human counterpart, is U2 snRNP specific [2].
 

Other interactions of U2A

  • Unexpectedly, however, we find that loss of function causes lethality, suggesting that U2A', but not SNF, is critical for U2 snRNP function [2].

References

  1. Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA. Price, S.R., Evans, P.R., Nagai, K. Nature (1998) [Pubmed]
  2. The Drosophila U2 snRNP protein U2A' has an essential function that is SNF/U2B" independent. Nagengast, A.A., Salz, H.K. Nucleic Acids Res. (2001) [Pubmed]
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