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Gene Review

Oda  -  Ornithine decarboxylase antizyme

Drosophila melanogaster

Synonyms: AZ, CG16747, D-AZ, Dmel\CG16747, ODA, ...
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High impact information on Oda

  • Panneural reduction of BRP expression by RNAi constructs permits a first functional characterization of this large AZ protein: larvae show reduced evoked but normal spontaneous transmission at neuromuscular junctions [1].
  • In the reverse orientation, within one of the introns of the Drosophila antizyme gene, the gene for snRNP Sm D3 is located [2].
  • The present study shows that homology of this coding sequence to its mammalian antizyme counterpart also extends to a 5' open reading frame (ORF) which encodes the amino-terminal part of antizyme and overlaps the +1 frame (ORF2) that encodes the carboxy-terminal three-quarters of the protein [2].
  • Antizyme is a target of sex-lethal in the Drosophila germline and appears to act downstream of hedgehog to regulate sex-lethal and cyclin B [3].
  • Interestingly, AZ inactivation causes a new phenotype characterized by late larval lethality and atrophy of the brain, imaginal discs, hematopoietic organs, and salivary glands [4].

Biological context of Oda


  1. Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in Drosophila. Wagh, D.A., Rasse, T.M., Asan, E., Hofbauer, A., Schwenkert, I., Dürrbeck, H., Buchner, S., Dabauvalle, M.C., Schmidt, M., Qin, G., Wichmann, C., Kittel, R., Sigrist, S.J., Buchner, E. Neuron (2006) [Pubmed]
  2. The Drosophila gene for antizyme requires ribosomal frameshifting for expression and contains an intronic gene for snRNP Sm D3 on the opposite strand. Ivanov, I.P., Simin, K., Letsou, A., Atkins, J.F., Gesteland, R.F. Mol. Cell. Biol. (1998) [Pubmed]
  3. Antizyme is a target of sex-lethal in the Drosophila germline and appears to act downstream of hedgehog to regulate sex-lethal and cyclin B. Vied, C., Halachmi, N., Salzberg, A., Horabin, J.I. Dev. Biol. (2003) [Pubmed]
  4. P elements inserted in the vicinity of or within the Drosophila snRNP SmD3 gene nested in the first intron of the Ornithine Decarboxylase Antizyme gene affect only the expression of SmD3. Schenkel, H., Hanke, S., De Lorenzo, C., Schmitt, R., Mechler, B.M. Genetics (2002) [Pubmed]
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