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Gene Review

Pia7  -  Pristane induced arthritis QTL 7

Rattus norvegicus

 
 
 
 
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High impact information on Pia7

  • Two novel loci affecting disease severity are identified on chromosome 1 (Pia8) and chromosome 4 (Pia7) respectively [1].
  • We found suggestive evidence for an interaction where an effect of Pia7 and Pia1 on disease severity depends on DA homozygosity at specific loci, which themselves do not confer susceptibility [1].

References

  1. Complex genetic control in a rat model for rheumatoid arthritis. Nordquist, N., Olofsson, P., Vingsbo-Lundberg, C., Petterson, U., Holmdahl, R. J. Autoimmun. (2000) [Pubmed]
 
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