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Gene Review

H2B  -  histone H2B

Strongylocentrotus purpuratus

 
 
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High impact information on H2B

  • Early embryonic H4 (EH4) and H2B (EH2B) and late embryonic H4 (LH4) histone genes were transcribed in vitro in a nuclear extract from hatching blastula embryos of the sea urchin Strongylocentrotus purpuratus [1].
  • Sea urchin sperm chromatin contains forms of H1, H2A, and H2B which differ from those present in adult tissues [2].
  • Comparisons of protein-coding sequences of late H4 and H2B genes with their early counterparts showed that silent sites have diverged to the theoretical maximum, indicating that early and late histone gene classes diverged at least 200 million years ago [3].
  • Amino acid sequences derived from nucleotide sequences of late H2A and H2B gistone genes differ substantially from amino acid sequences of their late counterparts [3].
  • In addition, we observed a delay in development of lithium-treated embryos that is accompanied by a delay in the expression of a late class histone H2B gene [4].

References

  1. Sea urchin early and late H4 histone genes bind a specific transcription factor in a stable preinitiation complex. Tung, L., Morris, G.F., Yager, L.N., Weinberg, E.S. Mol. Cell. Biol. (1989) [Pubmed]
  2. Structure of sea urchin sperm chromatin core particle. Simpson, R.T., Bergman, L.W. J. Biol. Chem. (1980) [Pubmed]
  3. Evolution of late H2A, H2B, and H4 histone genes of the sea urchin, Strongylocentrotus purpuratus. Maxson, R., Mohun, T., Gormezano, G., Kedes, L. Nucleic Acids Res. (1987) [Pubmed]
  4. Altered cell fate in LiCl-treated sea urchin embryos. Nocente-McGrath, C., McIsaac, R., Ernst, S.G. Dev. Biol. (1991) [Pubmed]
 
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