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Gene Review

mespa-a  -  mesoderm posterior homolog A

Xenopus laevis

Synonyms: hen2, hen2-a, thyl1, thyl2, thylacine1, ...
 
 
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High impact information on hen2-a

  • Expression of Thylacine is restricted to the presomitic mesoderm, localising to the anterior half of several somitomeres in register with domains of X-Delta-2 expression [1].
  • We show that Thylacine 1 and the Notch pathway establish segment identity one segment prior to the segmental expression of PAPC [2].
 

Associations of hen2-a with chemical compounds

  • Altering segmental identity in embryos by perturbing the activity of Thylacine 1 and the Notch pathway, or by treatment with a protein synthesis inhibitor, cycloheximide, leads to the predicted changes in the segmental expression of PAPC [2].

References

  1. Thylacine 1 is expressed segmentally within the paraxial mesoderm of the Xenopus embryo and interacts with the Notch pathway. Sparrow, D.B., Jen, W.C., Kotecha, S., Towers, N., Kintner, C., Mohun, T.J. Development (1998) [Pubmed]
  2. The protocadherin PAPC establishes segmental boundaries during somitogenesis in xenopus embryos. Kim, S.H., Jen, W.C., De Robertis, E.M., Kintner, C. Curr. Biol. (2000) [Pubmed]
 
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