The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

mespa-a  -  mesoderm posterior homolog A

Xenopus laevis

Synonyms: hen2, hen2-a, thyl1, thyl2, thylacine1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on hen2-a

  • Expression of Thylacine is restricted to the presomitic mesoderm, localising to the anterior half of several somitomeres in register with domains of X-Delta-2 expression [1].
  • We show that Thylacine 1 and the Notch pathway establish segment identity one segment prior to the segmental expression of PAPC [2].

Associations of hen2-a with chemical compounds

  • Altering segmental identity in embryos by perturbing the activity of Thylacine 1 and the Notch pathway, or by treatment with a protein synthesis inhibitor, cycloheximide, leads to the predicted changes in the segmental expression of PAPC [2].


  1. Thylacine 1 is expressed segmentally within the paraxial mesoderm of the Xenopus embryo and interacts with the Notch pathway. Sparrow, D.B., Jen, W.C., Kotecha, S., Towers, N., Kintner, C., Mohun, T.J. Development (1998) [Pubmed]
  2. The protocadherin PAPC establishes segmental boundaries during somitogenesis in xenopus embryos. Kim, S.H., Jen, W.C., De Robertis, E.M., Kintner, C. Curr. Biol. (2000) [Pubmed]
WikiGenes - Universities