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Gene Review:

EDNRB2 - endothelin receptor B subtype 2

Gallus gallus

Miwa, M. et al., Lecoin, L. et al.

Miwa, Inoue-Murayama, Kobayashi, Kayang, Mizutani, Takahashi, Ito,

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Disease relevance of EDNRB2

Because EDNRB is responsible for aganglionic megacolon and spot coat color in mouse, rat and equine, EDNRB2 is suggested to be a candidate gene for the s locus [1].

High impact information on EDNRB2

We report here the cloning by reverse transcriptase-PCR of an avian cDNA encoding a subtype of EDNR, which we have called EDNRB2, because its deduced amino acid sequence is more closely related to that of EDNRB than to either the mammalian EDNRA or to the Xenopus EDNRC [2].
In this region, the endothelin receptor B subtype 2 gene (EDNRB2), an avian-specific paralog of the mammalian endothelin receptor B gene (EDNRB), is located [1].

References

Mapping of panda plumage color locus on the microsatellite linkage map of the Japanese quail. Miwa, M., Inoue-Murayama, M., Kobayashi, N., Kayang, B.B., Mizutani, M., Takahashi, H., Ito, S. BMC Genet. (2006) [Pubmed]
Cloning and characterization of a novel endothelin receptor subtype in the avian class. Lecoin, L., Sakurai, T., Ngo, M.T., Abe, Y., Yanagisawa, M., Le Douarin, N.M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]

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