Gene Review:
EDNRA - endothelin receptor type A
Homo sapiens
Synonyms:
ET-A, ETA, ETA-R, ETAR, ETRA, ...
Arjomand-Nahad,
Landt,
Stangl,
Diefenbach,
Roots,
Yokomori,
Oda,
Yasogawa,
Nishi,
Ogi,
Takahashi,
Ishii,
Ishikawa,
Funayama,
Ohtake,
Kimura,
Ideta,
Nakamoto,
Yasuda,
Fukuchi,
Fujimaki,
Murakami,
Asaoka,
Hotta,
Kanamoto,
Tanihara,
Miyaki,
Mashima,
Kim,
Dhir,
Azadzoi,
Traish,
Flaherty,
Goldstein,
Guruli,
Pflug,
Pecher,
Makarenkova,
Shurin,
Nelson,
- Downregulation of endothelin B receptor in human melanoma cell lines parallel to differentiation genes. Eberle, J., Weitmann, S., Thieck, O., Pech, H., Paul, M., Orfanos, C.E. J. Invest. Dermatol. (1999)
- Association of EDNRA, but not WNK4 or FKBP1B, polymorphisms with essential hypertension. Benjafield, A.V., Katyk, K., Morris, B.J. Clin. Genet. (2003)
- Fifteen polymorphisms in endothelin-1, endothelin-2 and endothelin-receptor-A genotyped by four duplex assays and seven simple assays on a LightCycler using hybridization probes. Arjomand-Nahad, F., Landt, O., Stangl, K., Diefenbach, K., Roots, I. Clin. Chem. Lab. Med. (2006)
- Endothelin-1-induced prostaglandin E2-EP2, EP4 signaling regulates vascular endothelial growth factor production and ovarian carcinoma cell invasion. Spinella, F., Rosanò, L., Di Castro, V., Natali, P.G., Bagnato, A. J. Biol. Chem. (2004)
- Enhanced expression of endothelin B receptor at protein and gene levels in human cirrhotic liver. Yokomori, H., Oda, M., Yasogawa, Y., Nishi, Y., Ogi, M., Takahashi, M., Ishii, H. Am. J. Pathol. (2001)
- Pilot study of the endothelin-A receptor selective antagonist BMS-193884 for the treatment of erectile dysfunction. Kim, N.N., Dhir, V., Azadzoi, K.M., Traish, A.M., Flaherty, E., Goldstein, I. J. Androl. (2002)
- The antisense homology box: a new motif within proteins that encodes biologically active peptides. Baranyi, L., Campbell, W., Ohshima, K., Fujimoto, S., Boros, M., Okada, H. Nat. Med. (1995)
- Glucocorticoids regulate the expression of the human osteoblastic endothelin A receptor gene. Börcsök, I., Schairer, H.U., Sommer, U., Wakley, G.K., Schneider, U., Geiger, F., Niethard, F.U., Ziegler, R., Kasperk, C.H. J. Exp. Med. (1998)
- Blocking both type A and B endothelin receptors in the kidney attenuates renal injury and prolongs survival in rats with remnant kidney. Benigni, A., Zola, C., Corna, D., Orisio, S., Facchinetti, D., Benati, L., Remuzzi, G. Am. J. Kidney Dis. (1996)
- Mechanisms of osteoblastic metastases: role of endothelin-1. Mohammad, K.S., Guise, T.A. Clin. Orthop. Relat. Res. (2003)
- Endothelin A receptor blockade does not alter PSA secretion in prostate cancer cell lines. Pecher, S., Pflug, B.R., Brink, A.K., Nelson, J.B. Prostate (2004)
- Endothelin in heart failure: a promising therapeutic target? Love, M.P., McMurray, J.J. Heart (1997)
- Endothelin receptor antagonists in a beagle model of pulmonary hypertension: contribution to possible potential therapy? Okada, M., Yamashita, C., Okada, M., Okada, K. J. Am. Coll. Cardiol. (1995)
- Variants of endothelin-1 and its receptors in atopic asthma. Mao, X.Q., Gao, P.S., Roberts, M.H., Enomoto, T., Kawai, M., Sasaki, S., Shaldon, S.R., Coull, P., Dake, Y., Adra, C.N., Hagihara, A., Shirakawa, T., Hopkin, J.M. Biochem. Biophys. Res. Commun. (1999)
- Association between glaucoma and gene polymorphism of endothelin type A receptor. Ishikawa, K., Funayama, T., Ohtake, Y., Kimura, I., Ideta, H., Nakamoto, K., Yasuda, N., Fukuchi, T., Fujimaki, T., Murakami, A., Asaoka, R., Hotta, Y., Kanamoto, T., Tanihara, H., Miyaki, K., Mashima, Y. Mol. Vis. (2005)
- Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels. Seo, B., Oemar, B.S., Siebenmann, R., von Segesser, L., Lüscher, T.F. Circulation (1994)
- Function and survival of dendritic cells depend on endothelin-1 and endothelin receptor autocrine loops. Guruli, G., Pflug, B.R., Pecher, S., Makarenkova, V., Shurin, M.R., Nelson, J.B. Blood (2004)
- Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts. Shi-Wen, X., Chen, Y., Denton, C.P., Eastwood, M., Renzoni, E.A., Bou-Gharios, G., Pearson, J.D., Dashwood, M., du Bois, R.M., Black, C.M., Leask, A., Abraham, D.J. Mol. Biol. Cell (2004)
- Endothelin receptor antagonists in congestive heart failure: a new therapeutic principle for the future? Spieker, L.E., Noll, G., Ruschitzka, F.T., Lüscher, T.F. J. Am. Coll. Cardiol. (2001)
- Tyr-129 is important to the peptide ligand affinity and selectivity of human endothelin type A receptor. Lee, J.A., Elliott, J.D., Sutiphong, J.A., Friesen, W.J., Ohlstein, E.H., Stadel, J.M., Gleason, J.G., Peishoff, C.E. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Structural basis of G protein specificity of human endothelin receptors. A study with endothelinA/B chimeras. Takagi, Y., Ninomiya, H., Sakamoto, A., Miwa, S., Masaki, T. J. Biol. Chem. (1995)
- Endothelin A receptor antagonism and angiotensin-converting enzyme inhibition are synergistic via an endothelin B receptor-mediated and nitric oxide-dependent mechanism. Goddard, J., Eckhart, C., Johnston, N.R., Cumming, A.D., Rankin, A.J., Webb, D.J. J. Am. Soc. Nephrol. (2004)
- The ligand-receptor interactions of the endothelin systems are mediated by distinct "message" and "address" domains. Sakamoto, A., Yanagisawa, M., Sakurai, T., Nakao, K., Toyo-oka, T., Yano, M., Masaki, T. J. Cardiovasc. Pharmacol. (1993)
- Molecular characterization and regulation of the human endothelin receptors. Elshourbagy, N.A., Korman, D.R., Wu, H.L., Sylvester, D.R., Lee, J.A., Nuthalaganti, P., Bergsma, D.J., Kumar, C.S., Nambi, P. J. Biol. Chem. (1993)
- Regulated interaction of endothelin B receptor with caveolin-1. Yamaguchi, T., Murata, Y., Fujiyoshi, Y., Doi, T. Eur. J. Biochem. (2003)
- Endothelin-1 induces tyrosine phosphorylation in human blood monocytes. Chisholm, L.J., Agrawal, D.K., Pearson, T.J., Edwards, J.D. Mol. Cell. Biochem. (1996)
- Endothelin-1 potentiates human smooth muscle cell growth to PDGF: effects of ETA and ETB receptor blockade. Yang, Z., Krasnici, N., Lüscher, T.F. Circulation (1999)
- Localization of endothelin immunoreactivity and demonstration of constrictory endothelin-A receptors in human coronary arteries and veins. Saetrum Opgaard, O., Adner, M., Gulbenkian, S., Edvinsson, L. J. Cardiovasc. Pharmacol. (1994)
- Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity. Freedman, N.J., Ament, A.S., Oppermann, M., Stoffel, R.H., Exum, S.T., Lefkowitz, R.J. J. Biol. Chem. (1997)
- Up-regulated inflammatory factors endothelin, NFkappaB, TNFalpha and iNOS involved in exaggerated cardiac arrhythmias in l-thyroxine-induced cardiomyopathy are suppressed by darusentan in rats. Xia, H.J., Dai, D.Z., Dai, Y. Life Sci. (2006)
- Endothelin-3 mediated proliferation in wounded human umbilical vein endothelial cells. Wren, A.D., Hiley, C.R., Fan, T.P. Biochem. Biophys. Res. Commun. (1993)
- Effects of systemic endothelin A receptor antagonism in various vascular beds in men: in vivo interactions of the major blood pressure-regulating systems and associations with the GNB3 C825T polymorphism. Mitchell, A., Lückebergfeld, B., Bührmann, S., Rushentsova, U., Nürnberger, J., Siffert, W., Schäfers, R.F., Philipp, T., Wenzel, R.R. Clin. Pharmacol. Ther. (2004)