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Gene Review

TBX2  -  T-box 2

Gallus gallus

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High impact information on TBX2

  • Tbx3 nor Tbx2 can substitute for LMP-4 binding [1].
  • Shh downregulation occurs via a local BMP-Tbx2 pathway, Tbx2 acting to repress Shh expression [2].


  1. Tbx5 and Tbx4 transcription factors interact with a new chicken PDZ-LIM protein in limb and heart development. Krause, A., Zacharias, W., Camarata, T., Linkhart, B., Law, E., Lischke, A., Miljan, E., Simon, H.G. Dev. Biol. (2004) [Pubmed]
  2. Regional Morphogenesis in the Hypothalamus: A BMP-Tbx2 Pathway Coordinates Fate and Proliferation through Shh Downregulation. Manning, L., Ohyama, K., Saeger, B., Hatano, O., Wilson, S.A., Logan, M., Placzek, M. Dev. Cell (2006) [Pubmed]
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