Gene Review:
sirA - iron-regulated lipoprotein
Staphylococcus aureus RF122
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High impact information on sirA
- Mutation of either sirA or sirB increased the resistance of iron-starved S. aureus to streptonigrin and resulted in compromised growth in iron-restricted, but not iron-rich, media [1].
Biological context of sirA
- Moreover, we found that transcription from the sbn operon was increased, relative to the wild type, in both sirA and sirB knockout strains, likely in response to an increased level of iron starvation in these cells [1].
Associations of sirA with chemical compounds
- We also demonstrated that sirA and sirB mutants are compromised in the ability to transport iron complexed to staphylobactin but are not compromised for uptake of other iron complexes, such as ferric hydroxamates, ferric enterobactin, or ferric citrate [1].
References
- Involvement of SirABC in iron-siderophore import in Staphylococcus aureus. Dale, S.E., Sebulsky, M.T., Heinrichs, D.E. J. Bacteriol. (2004) [Pubmed]
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