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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

key  -  kenny

Drosophila melanogaster

Synonyms: CG16910, DmIKK-gamma, DmIKKgamma, Dmel\CG16910, Dmikkgamma, ...
 
 
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Disease relevance of key

  • Our data show that Drosophila IKK gamma is required for the Relish-dependent immune induction of the genes encoding antibacterial peptides and for resistance to infections by Escherichia coli [1].
 

High impact information on key

  • Here we report the identification of a Drosophila IkappaB kinase complex containing DmIKKbeta and DmIKKgamma, homologs of the human IKKbeta and IKKgamma proteins [2].
 

Biological context of key

  • We have generated, by ethylmethane sulfonate mutagenesis, loss-of-function mutants in the Drosophila homolog of the mammalian I-kappa B kinase (IKK) complex component IKK gamma (also called NEMO) [1].

References

  1. Role of Drosophila IKK gamma in a toll-independent antibacterial immune response. Rutschmann, S., Jung, A.C., Zhou, R., Silverman, N., Hoffmann, J.A., Ferrandon, D. Nat. Immunol. (2000) [Pubmed]
  2. A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity. Silverman, N., Zhou, R., Stöven, S., Pandey, N., Hultmark, D., Maniatis, T. Genes Dev. (2000) [Pubmed]
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