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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ldb1  -  LIM domain binding 1

Xenopus laevis

Synonyms: chi, clim2, nli, xldb1
 
 
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High impact information on chi

  • In animal explant experiments, synergism of Ldb1 with Xlim-1 in the activation of downstream genes required both the region containing the dimerization domain of Ldb1 and the region containing the LIM-binding domain [1].
  • In this study we localized the transcriptional activation domain of Xlim-1 to its carboxyl-terminal region, and characterized the interactions of the amino-terminally located LIM domains with Ldb1 [1].
  • We have cloned and sequenced the genes corresponding to the membrane exons of the three immunoglobulin (Ig) heavy chain isotypes (mu, upsilon and chi) of Xenopus [2].

References

  1. Interactions between LIM domains and the LIM domain-binding protein Ldb1. Breen, J.J., Agulnick, A.D., Westphal, H., Dawid, I.B. J. Biol. Chem. (1998) [Pubmed]
  2. Membrane exon sequences of the three Xenopus Ig classes explain the evolutionary origin of mammalian isotypes. Mussmann, R., Wilson, M., Marcuz, A., Courtet, M., Du Pasquier, L. Eur. J. Immunol. (1996) [Pubmed]
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