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Gene Review:

Bro - Brother

Drosophila melanogaster

Synonyms: CG7960, Dmel\CG7960, Protein brother, bro, rpbeta1

Golling, G. et al., Li, L.H. et al., Kaminker, J.S. et al.

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High impact information on Bro

Yeast two-hybrid experiments as well as in vitro DNA-binding studies confirmed the functional homology of the Brother, Big-brother, and PEBP2/CBF beta proteins and demonstrated that the conserved regions of the Runt and Brother proteins are required for their heterodimeric interaction [1].
Using the yeast two-hybrid system to isolate cDNAs for Runt-interacting proteins, we identified two Drosophila genes, referred to as Brother and Big-brother, that have substantial sequence homology with PEBP2/CBF beta [1].
First, we show that a specific point mutation in Runt that disrupts interaction with Brother proteins but does not affect DNA binding activity is dysfunctional in several in vivo assays [2].

Other interactions of Bro

Redundant function of Runt Domain binding partners, Big brother and Brother, during Drosophila development [3].

References

Drosophila homologs of the proto-oncogene product PEBP2/CBF beta regulate the DNA-binding properties of Runt. Golling, G., Li, L., Pepling, M., Stebbins, M., Gergen, J.P. Mol. Cell. Biol. (1996) [Pubmed]
Differential interactions between Brother proteins and Runt domain proteins in the Drosophila embryo and eye. Li, L.H., Gergen, J.P. Development (1999) [Pubmed]
Redundant function of Runt Domain binding partners, Big brother and Brother, during Drosophila development. Kaminker, J.S., Singh, R., Lebestky, T., Yan, H., Banerjee, U. Development (2001) [Pubmed]

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