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Gene Review

Eip63E  -  Ecdysone-induced protein 63E

Drosophila melanogaster

Synonyms: CG10579, Dmel\CG10579, EIP63E, L63, PFTAIRE, ...
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High impact information on Eip63E

  • The 71-nt Drosophila U7 snRNA is encoded by a single gene that is embedded in the direct orientation in an intron of the Eip63E gene [1].
  • L63 proteins are widely distributed among late larval and prepupal tissues and are unlikely to be involved in cell cycle functions [2].
  • PIF-1A and PIF-1B (the L63 interactor) predicted proteins are expressed in vivo, and show a distinct expression profile during development [3].
  • L63 encodes a CDK-like protein homologous to the mammalian PFTAIRE [3].
  • In addition, we describe two novel Drosophila proteins, PIF-1 and PIF-2 (for PFTAIRE Interacting Factor-1 and -2), identified in a two-hybrid screen for their ability to interact with the amino-terminal region of L63 [3].

Other interactions of Eip63E

  • The role of this interaction remains to be demonstrated, but our data suggest that PIF-1B might serve as a regulator of L63 [3].
  • We showed previously that L63 provides a CDK-related function critical to development (Dev. Biol. 221 (2000) 23) [3].

Analytical, diagnostic and therapeutic context of Eip63E


  1. Cloning and characterization of the Drosophila U7 small nuclear RNA. Dominski, Z., Yang, X.C., Purdy, M., Marzluff, W.F. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. The L63 gene is necessary for the ecdysone-induced 63E late puff and encodes CDK proteins required for Drosophila development. Stowers, R.S., Garza, D., Rascle, A., Hogness, D.S. Dev. Biol. (2000) [Pubmed]
  3. L63, the Drosophila PFTAIRE, interacts with two novel proteins unrelated to cyclins. Rascle, A., Stowers, R.S., Garza, D., Lepesant, J.A., Hogness, D.S. Mech. Dev. (2003) [Pubmed]
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