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Gene Review

REP15  -  RAB15 effector protein

Homo sapiens

Synonyms: RAB15EP, Rab15 effector protein
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High impact information on REP15

  • Consistent with its localization, REP15 overexpression and small interfering RNA-mediated depletion inhibited transferrin receptor recycling from the endocytic recycling compartment, without affecting receptor entry into or recycling from sorting endosomes [1].
  • We previously reported that Rab15 differentially regulates transferrin receptor trafficking through sorting endosomes and the endocytic recycling compartment, suggesting a role for distinct Rab15-effector interactions at these endocytic compartments [1].


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