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Gene Review

SDC4  -  syndecan 4

Sus scrofa

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High impact information on SDC4

  • In acute vascular rejection, heparan sulfate and syndecan-4-phosphate, which can aid in complement control, were nearly absent, whereas in accommodation these were present in heightened amounts [1].
  • In addition, PR39 also stimulates expression of the FGF receptors (FGFR)-1 and syndecan-4 [2].


  1. Acute vascular rejection and accommodation: divergent outcomes of the humoral response to organ transplantation. Williams, J.M., Holzknecht, Z.E., Plummer, T.B., Lin, S.S., Brunn, G.J., Platt, J.L. Transplantation (2004) [Pubmed]
  2. Adenoviral PR39 improves blood flow and myocardial function in a pig model of chronic myocardial ischemia by enhancing collateral formation. Post, M.J., Sato, K., Murakami, M., Bao, J., Tirziu, D., Pearlman, J.D., Simons, M. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2006) [Pubmed]
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