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Gene Review:

mcm7-a - minichromosome maintenance complex...

Xenopus laevis

Romanowski, P. et al., Ohno, K. et al.

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High impact information on LOC397852

Immunodepletion of the MCM complex from Xenopus egg extract by anti-XMCM7 antibodies inhibits DNA replication of sperm and permeable HeLa G2 nuclei but not permeable HeLa G1 nuclei [1].
The deduced amino-acid sequences displayed 60, 59 and 68% identities with the respective Xenopus laevis homologues, XMCM3, XMCM6 and XMCM7 [2].

Biological context of LOC397852

XMCM7 does not preferentially colocalize with sites of DNA replication but colocalizes with XMCM3 throughout replication [1].

References

XMCM7, a novel member of the Xenopus MCM family, interacts with XMCM3 and colocalizes with it throughout replication. Romanowski, P., Madine, M.A., Laskey, R.A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
cDNA cloning and expression during development of Drosophila melanogaster MCM3, MCM6 and MCM7. Ohno, K., Hirose, F., Inoue, Y.H., Takisawa, H., Mimura, S., Hashimoto, Y., Kiyono, T., Nishida, Y., Matsukage, A. Gene (1998) [Pubmed]

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