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MeSH Review

DNA Replication

 
 
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Disease relevance of DNA Replication

 

High impact information on DNA Replication

  • DNA mismatch repair (MMR) is an evolutionarily conserved process that corrects mismatches generated during DNA replication and escape proofreading [6].
  • Biochemical and genetic evidence document a key role for pol gamma in mitochondrial DNA replication, and whereas DNA repair and recombination were thought to be limited or absent in animal mitochondria, both have been demonstrated in recent years [7].
  • MCM proteins in DNA replication [8].
  • Evidence from various organisms suggests that several factors influence telomere length regulation, such as telomere binding proteins, telomere capping proteins, telomerase, and DNA replication enzymes [9].
  • TopBP1, the vertebrate homolog of yeast Cut5/Dbp11, has dual roles in initiation of DNA replication and regulation of checkpoint responses [10].
 

Chemical compound and disease context of DNA Replication

 

Biological context of DNA Replication

 

Anatomical context of DNA Replication

 

Associations of DNA Replication with chemical compounds

  • When DNA replication is blocked by hydroxyurea, pHi continues to oscillate with a similar period as the uninhibited division cycle [26].
  • L1 mRNA accumulates in the cytoplasm in the presence of cycloheximide, which blocks DNA replication and the onset of the late phase [27].
  • Inhibition of protein synthesis during the lytic cycle with chloramphenicol inhibited Mu DNA synthesis with a half-life of approximately 3 min, demonstrating a need for continued protein synthesis to maintain Mu DNA replication [2].
  • The removal of the methyl moiety from the complementary strand takes place after a delay of at least 48 hr, and both events are actively carried out in the absence of DNA replication [28].
  • Activation of RNA cap methylation is inhibited by aphidicolin, but not by actinomycin D, suggesting that this process is temporally coordinated with DNA replication, but independent of RNA transcription [29].
 

Gene context of DNA Replication

 

Analytical, diagnostic and therapeutic context of DNA Replication

References

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  7. DNA polymerase gamma, the mitochondrial replicase. Kaguni, L.S. Annu. Rev. Biochem. (2004) [Pubmed]
  8. MCM proteins in DNA replication. Tye, B.K. Annu. Rev. Biochem. (1999) [Pubmed]
  9. Telomere length regulation. Greider, C.W. Annu. Rev. Biochem. (1996) [Pubmed]
  10. TopBP1 activates the ATR-ATRIP complex. Kumagai, A., Lee, J., Yoo, H.Y., Dunphy, W.G. Cell (2006) [Pubmed]
  11. E. coli SeqA protein binds oriC in two different methyl-modulated reactions appropriate to its roles in DNA replication initiation and origin sequestration. Slater, S., Wold, S., Lu, M., Boye, E., Skarstad, K., Kleckner, N. Cell (1995) [Pubmed]
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  21. Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Girard, F., Strausfeld, U., Fernandez, A., Lamb, N.J. Cell (1991) [Pubmed]
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  25. A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus. Forrester, W.C., Epner, E., Driscoll, M.C., Enver, T., Brice, M., Papayannopoulou, T., Groudine, M. Genes Dev. (1990) [Pubmed]
  26. Cytoplasmic pH and the regulation of the Dictyostelium cell cycle. Aerts, R.J., Durston, A.J., Moolenaar, W.H. Cell (1985) [Pubmed]
  27. Transcripts from the adenovirus-2 major late promoter yield a single early family of 3' coterminal mRNAs and five late families. Shaw, A.R., Ziff, E.B. Cell (1980) [Pubmed]
  28. Dynamics of demethylation and activation of the alpha-actin gene in myoblasts. Paroush, Z., Keshet, I., Yisraeli, J., Cedar, H. Cell (1990) [Pubmed]
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  30. D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Xiong, Y., Zhang, H., Beach, D. Cell (1992) [Pubmed]
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  35. Interaction of E1 and hSNF5 proteins stimulates replication of human papillomavirus DNA. Lee, D., Sohn, H., Kalpana, G.V., Choe, J. Nature (1999) [Pubmed]
  36. Immunoassay for urothelial cancers that detects DNA replication protein Mcm5 in urine. Stoeber, K., Halsall, I., Freeman, A., Swinn, R., Doble, A., Morris, L., Coleman, N., Bullock, N., Laskey, R.A., Hales, C.N., Williams, G.H. Lancet (1999) [Pubmed]
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