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MeSH Review

DNA Replication

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Disease relevance of DNA Replication


High impact information on DNA Replication

  • DNA mismatch repair (MMR) is an evolutionarily conserved process that corrects mismatches generated during DNA replication and escape proofreading [6].
  • Biochemical and genetic evidence document a key role for pol gamma in mitochondrial DNA replication, and whereas DNA repair and recombination were thought to be limited or absent in animal mitochondria, both have been demonstrated in recent years [7].
  • MCM proteins in DNA replication [8].
  • Evidence from various organisms suggests that several factors influence telomere length regulation, such as telomere binding proteins, telomere capping proteins, telomerase, and DNA replication enzymes [9].
  • TopBP1, the vertebrate homolog of yeast Cut5/Dbp11, has dual roles in initiation of DNA replication and regulation of checkpoint responses [10].

Chemical compound and disease context of DNA Replication


Biological context of DNA Replication


Anatomical context of DNA Replication


Associations of DNA Replication with chemical compounds

  • When DNA replication is blocked by hydroxyurea, pHi continues to oscillate with a similar period as the uninhibited division cycle [26].
  • L1 mRNA accumulates in the cytoplasm in the presence of cycloheximide, which blocks DNA replication and the onset of the late phase [27].
  • Inhibition of protein synthesis during the lytic cycle with chloramphenicol inhibited Mu DNA synthesis with a half-life of approximately 3 min, demonstrating a need for continued protein synthesis to maintain Mu DNA replication [2].
  • The removal of the methyl moiety from the complementary strand takes place after a delay of at least 48 hr, and both events are actively carried out in the absence of DNA replication [28].
  • Activation of RNA cap methylation is inhibited by aphidicolin, but not by actinomycin D, suggesting that this process is temporally coordinated with DNA replication, but independent of RNA transcription [29].

Gene context of DNA Replication


Analytical, diagnostic and therapeutic context of DNA Replication


  1. Initiation of transcription at phage T4 late promoters with purified RNA polymerase. Kassavetis, G.A., Elliott, T., Rabussay, D.P., Geiduschek, E.P. Cell (1983) [Pubmed]
  2. Instability of transposase activity: evidence from bacteriophage mu DNA replication. Pato, M.L., Reich, C. Cell (1982) [Pubmed]
  3. A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication. Jones, K.A., Kadonaga, J.T., Rosenfeld, P.J., Kelly, T.J., Tjian, R. Cell (1987) [Pubmed]
  4. Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein, EBNA1, bound to DNA. Bochkarev, A., Barwell, J.A., Pfuetzner, R.A., Bochkareva, E., Frappier, L., Edwards, A.M. Cell (1996) [Pubmed]
  5. Formation of DNA replication structures in herpes virus-infected cells requires a viral DNA binding protein. de Bruyn Kops, A., Knipe, D.M. Cell (1988) [Pubmed]
  6. DNA mismatch repair. Kunkel, T.A., Erie, D.A. Annu. Rev. Biochem. (2005) [Pubmed]
  7. DNA polymerase gamma, the mitochondrial replicase. Kaguni, L.S. Annu. Rev. Biochem. (2004) [Pubmed]
  8. MCM proteins in DNA replication. Tye, B.K. Annu. Rev. Biochem. (1999) [Pubmed]
  9. Telomere length regulation. Greider, C.W. Annu. Rev. Biochem. (1996) [Pubmed]
  10. TopBP1 activates the ATR-ATRIP complex. Kumagai, A., Lee, J., Yoo, H.Y., Dunphy, W.G. Cell (2006) [Pubmed]
  11. E. coli SeqA protein binds oriC in two different methyl-modulated reactions appropriate to its roles in DNA replication initiation and origin sequestration. Slater, S., Wold, S., Lu, M., Boye, E., Skarstad, K., Kleckner, N. Cell (1995) [Pubmed]
  12. Effect of novobiocin on initiation of DNA replication in Bacillus subtilis. Ogasawara, N., Seiki, M., Yoshikawa, H. Nature (1979) [Pubmed]
  13. Intron mobility in phage T4 occurs in the context of recombination-dependent DNA replication by way of multiple pathways. Mueller, J.E., Clyman, J., Huang, Y.J., Parker, M.M., Belfort, M. Genes Dev. (1996) [Pubmed]
  14. Reduction of the toxicity and mutagenicity of alkylating agents in mammalian cells harboring the Escherichia coli alkyltransferase gene. Brennand, J., Margison, G.P. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  15. Function of adenovirus terminal protein in the initiation of DNA replication. Tamanoi, F., Stillman, B.W. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  16. Reversal of terminal differentiation and control of DNA replication: cyclin A and Cdk2 specifically localize at subnuclear sites of DNA replication. Cardoso, M.C., Leonhardt, H., Nadal-Ginard, B. Cell (1993) [Pubmed]
  17. An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele. Maser, R.S., Zinkel, R., Petrini, J.H. Nat. Genet. (2001) [Pubmed]
  18. Unstable amplification of an altered dihydrofolate reductase gene associated with double-minute chromosomes. Haber, D.A., Schimke, R.T. Cell (1981) [Pubmed]
  19. A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle. Levin, D.E., Fields, F.O., Kunisawa, R., Bishop, J.M., Thorner, J. Cell (1990) [Pubmed]
  20. Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Aparicio, O.M., Weinstein, D.M., Bell, S.P. Cell (1997) [Pubmed]
  21. Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Girard, F., Strausfeld, U., Fernandez, A., Lamb, N.J. Cell (1991) [Pubmed]
  22. A positive transcription factor controls the differential expression of two 5S RNA genes. Brown, D.D., Schlissel, M.S. Cell (1985) [Pubmed]
  23. Yph1p, an ORC-interacting protein: potential links between cell proliferation control, DNA replication, and ribosome biogenesis. Du, Y.C., Stillman, B. Cell (2002) [Pubmed]
  24. Cell- and promoter-specific activation of transcription by DNA replication. Grass, D.S., Read, D., Lewis, E.D., Manley, J.L. Genes Dev. (1987) [Pubmed]
  25. A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus. Forrester, W.C., Epner, E., Driscoll, M.C., Enver, T., Brice, M., Papayannopoulou, T., Groudine, M. Genes Dev. (1990) [Pubmed]
  26. Cytoplasmic pH and the regulation of the Dictyostelium cell cycle. Aerts, R.J., Durston, A.J., Moolenaar, W.H. Cell (1985) [Pubmed]
  27. Transcripts from the adenovirus-2 major late promoter yield a single early family of 3' coterminal mRNAs and five late families. Shaw, A.R., Ziff, E.B. Cell (1980) [Pubmed]
  28. Dynamics of demethylation and activation of the alpha-actin gene in myoblasts. Paroush, Z., Keshet, I., Yisraeli, J., Cedar, H. Cell (1990) [Pubmed]
  29. The role of cap methylation in the translational activation of stored maternal histone mRNA in sea urchin embryos. Caldwell, D.C., Emerson, C.P. Cell (1985) [Pubmed]
  30. D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Xiong, Y., Zhang, H., Beach, D. Cell (1992) [Pubmed]
  31. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Rountree, M.R., Bachman, K.E., Baylin, S.B. Nat. Genet. (2000) [Pubmed]
  32. Mitochondrial DNA synthesis in cell cycle mutants of Saccharomyces cerevisiae. Newlon, C.S., Fangman, W.L. Cell (1975) [Pubmed]
  33. The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing. Bell, S.P., Mitchell, J., Leber, J., Kobayashi, R., Stillman, B. Cell (1995) [Pubmed]
  34. Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor. Kubota, Y., Mimura, S., Nishimoto, S., Takisawa, H., Nojima, H. Cell (1995) [Pubmed]
  35. Interaction of E1 and hSNF5 proteins stimulates replication of human papillomavirus DNA. Lee, D., Sohn, H., Kalpana, G.V., Choe, J. Nature (1999) [Pubmed]
  36. Immunoassay for urothelial cancers that detects DNA replication protein Mcm5 in urine. Stoeber, K., Halsall, I., Freeman, A., Swinn, R., Doble, A., Morris, L., Coleman, N., Bullock, N., Laskey, R.A., Hales, C.N., Williams, G.H. Lancet (1999) [Pubmed]
  37. Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication. Jiang, W., McDonald, D., Hope, T.J., Hunter, T. EMBO J. (1999) [Pubmed]
  38. Dynamic organization of DNA replication in mammalian cell nuclei: spatially and temporally defined replication of chromosome-specific alpha-satellite DNA sequences. O'Keefe, R.T., Henderson, S.C., Spector, D.L. J. Cell Biol. (1992) [Pubmed]
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