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Gene Review

xcdc6  -  Cdc6-related protein

Xenopus laevis

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High impact information on Xcdc6

  • In postreplicative nuclei, Xcdc6 is associated with the nuclear envelope [1].
  • Xcdc6 binds to chromatin at the beginning of interphase but disappears from chromatin upon initiation of replication [1].
  • Using immunodepletion/add-back experiments in Xenopus egg extracts, we have determined that both Walker A (ATP binding) and Walker B (ATP hydrolysis) motifs of Xenopus Cdc6 (Xcdc6) are essential, but have distinct functional roles [2].


  1. The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. Coleman, T.R., Carpenter, P.B., Dunphy, W.G. Cell (1996) [Pubmed]
  2. Xenopus Cdc6 performs separate functions in initiating DNA replication. Frolova, N.S., Schek, N., Tikhmyanova, N., Coleman, T.R. Mol. Biol. Cell (2002) [Pubmed]
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