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Gene Review:

glyA - serine hydroxymethyltransferase

Escherichia coli UTI89

Makart, S. et al., Bhatt, A.N. et al.

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Disease relevance of glyA

A similar unfolding pathway has been reported for Escherichia coli aspartate aminotransferase, a member of the type I fold family of PLP binding enzymes such as SHMT, the sequence of which is only slightly identical ( approximately 14%) with that of SHMT [1].

High impact information on glyA

Therefore, we elaborated the optimum induction procedure for production of the biocatalytically promising serine hydroxymethyltransferase and found volumetric and specific productivity to increase with specific growth rate in glucose-limited fed-batch cultures [2].

References

Different unfolding pathways for mesophilic and thermophilic homologues of serine hydroxymethyltransferase. Bhatt, A.N., Prakash, K., Subramanya, H.S., Bhakuni, V. Biochemistry (2002) [Pubmed]
Characterization of the AlkS/P(alkB)-expression system as an efficient tool for the production of recombinant proteins in Escherichia coli fed-batch fermentations. Makart, S., Heinemann, M., Panke, S. Biotechnol. Bioeng. (2007) [Pubmed]

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