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Gene Review

GALC  -  galactosylceramidase

Canis lupus familiaris

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Disease relevance of GALC

  • Globoid cell leukodystrophy (GLD) or Krabbe disease is an autosomal recessively inherited neurological disease caused by mutations in the gene coding for the lysosomal enzyme galacto-cerebrosidase (GALC) [1].

High impact information on GALC

  • These galactosphingolipids are normally synthesized during active myelination, and psychosine accumulates in individuals with very low GALC activity [1].
  • GALC is responsible for the degradation of specific galactolipids, including several that are important in the production of compact, stable myelin [1].


  1. Murine, canine and non-human primate models of Krabbe disease. Wenger, D.A. Molecular medicine today. (2000) [Pubmed]
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