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Chemical Compound Review

Acetylin     2-acetyloxybenzoic acid

Synonyms: Acetysal, Colfarit, Magnecyl, Solupsan, Acylpyrin, ...
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Disease relevance of ACETYLSALICYLIC ACID


Psychiatry related information on ACETYLSALICYLIC ACID


High impact information on ACETYLSALICYLIC ACID


Chemical compound and disease context of ACETYLSALICYLIC ACID


Biological context of ACETYLSALICYLIC ACID


Anatomical context of ACETYLSALICYLIC ACID

  • After longer periods of time, however, pathological changes within the grafts appear considerably improved with only occasional evidence of myelin loss, little endoneurial oedema and few globoid cells [13].
  • Histologically, a gradual disappearance of globoid cells, the histological hallmark of Krabbe's disease, and the appearance of foamy macrophages capable of metabolizing the storage product were seen in the CNS [22].
  • CONCLUSION: Aspirin use among patients undergoing stress echocardiography was independently associated with reduced long-term all-cause mortality, particularly among older patients, those with known coronary artery disease, and those with impaired exercise capacity [23].
  • BACKGROUND: Aspirin products are known to cause irritation and injury to the gastric mucosa [24].
  • Study of isolated mitochondria confirmed that acetylsalicylate itself did not significantly affect mitochondrial respiration, respiratory control ratio, or ADP:O ratio [25].

Associations of ACETYLSALICYLIC ACID with other chemical compounds



  • BACKGROUND AND AIMS: Aspirin exerts antitumor effect partly through blocking tumor promoter-induced activator protein-1 (AP-1) activation [31].
  • Since salicylates have been reported to inhibit NF-kappa B activation by preventing the degradation of its inhibitor I kappa B, we studied a potential inhibition of this pathway by acetylsalicylate (aspirin) in human umbilical vein endothelial cells (HUVECs) [32].
  • Galactocerebrosidase (GALC) activity is deficient in all patients with globoid cell leukodystrophy (GLD) [33].
  • A mutation in the saposin A domain of the sphingolipid activator protein (prosaposin) gene results in a late-onset, chronic form of globoid cell leukodystrophy in the mouse [34].
  • The expression of glial fibrillary acidic protein (GFAP) was found to be markedly enhanced immunohistochemically and biochemically both in the central (CNS) and peripheral (PNS) nervous systems of the twitcher mutant, an authentic murine model of human globoid cell leukodystrophy [35].

Analytical, diagnostic and therapeutic context of ACETYLSALICYLIC ACID


  1. Letter: Aspirin and myocardial infarction. Elwood, P.C., Bainton, D. N. Engl. J. Med. (1975) [Pubmed]
  2. Absence of MHC class II molecules reduces CNS demyelination, microglial/macrophage infiltration, and twitching in murine globoid cell leukodystrophy. Matsushima, G.K., Taniike, M., Glimcher, L.H., Grusby, M.J., Frelinger, J.A., Suzuki, K., Ting, J.P. Cell (1994) [Pubmed]
  3. Peripheral nerve grafts in hereditary leukodystrophic mutant mice (twitcher). Scaravilli, F., Jacobs, J.M. Nature (1981) [Pubmed]
  4. Aspirin and nonsteroidal anti-inflammatory agents and risk for colorectal adenomas. Sandler, R.S., Galanko, J.C., Murray, S.C., Helm, J.F., Woosley, J.T. Gastroenterology (1998) [Pubmed]
  5. Effects of 11-week increases in dietary eicosapentaenoic acid on bleeding time, lipids, and platelet aggregation. Thorngren, M., Gustafson, A. Lancet (1981) [Pubmed]
  6. Anti-inflammatory treatment with acetylsalicylate or rofecoxib is not neuroprotective in Huntington's disease transgenic mice. Norflus, F., Nanje, A., Gutekunst, C.A., Shi, G., Cohen, J., Bejarano, M., Fox, J., Ferrante, R.J., Hersch, S.M. Neurobiol. Dis. (2004) [Pubmed]
  7. Biochemical, genetic, psychometric, and neuropsychological studies in heterozygotes of a family with globoid cell leucodystrophy (Krabbe's disease). Christomanou, H., Jaffé, S., Martinius, J., Cáp, C., Betke, K. Hum. Genet. (1981) [Pubmed]
  8. Effect of vitamins and aspirin on markers of platelet activation, oxidative stress and homocysteine in people at high risk of dementia. Clarke, R., Harrison, G., Richards, S. J. Intern. Med. (2003) [Pubmed]
  9. Does aspirin protect against Alzheimer's dementia? A study in a Swedish population-based sample aged > or =80 years. Nilsson, S.E., Johansson, B., Takkinen, S., Berg, S., Zarit, S., McClearn, G., Melander, A. Eur. J. Clin. Pharmacol. (2003) [Pubmed]
  10. Rapid treatment of percodan addiction: a case report. Goldstein, E., Pollack, R., Weiner, B., Lazoritz, M. The International journal of the addictions. (1978) [Pubmed]
  11. Hematopoietic stem-cell transplantation in globoid-cell leukodystrophy. Krivit, W., Shapiro, E.G., Peters, C., Wagner, J.E., Cornu, G., Kurtzberg, J., Wenger, D.A., Kolodny, E.H., Vanier, M.T., Loes, D.J., Dusenbery, K., Lockman, L.A. N. Engl. J. Med. (1998) [Pubmed]
  12. Letter: Aspirin and lymphocyte transformation. Lockshin, M.D. N. Engl. J. Med. (1975) [Pubmed]
  13. Enzyme replacement in grafted nerve of twitcher mouse. Scaravilli, F., Suzuki, K. Nature (1983) [Pubmed]
  14. Acetylsalicylic acid suppresses the renal hemodynamic effect and reduces the diuretic action of furosemide in cirrhosis with ascites. Planas, R., Arroyo, V., Rimola, A., Pérez-Ayuso, R.M., Rodés, J. Gastroenterology (1983) [Pubmed]
  15. Inhibition of acute inflammation in the periphery by central action of salicylates. Catania, A., Arnold, J., Macaluso, A., Hiltz, M.E., Lipton, J.M. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  16. Thromboxane biosynthesis in cardiovascular diseases. Patrono, C., Ciabattoni, G., Davi, G. Stroke (1990) [Pubmed]
  17. Topical acetylsalicylic, salicylic acid and indomethacin suppress pain from experimental tissue acidosis in human skin. Steen, K.H., Reeh, P.W., Kreysel, H.W. Pain (1995) [Pubmed]
  18. Kinetics of inhibition of purified and mitochondrial cytochrome c oxidase by psychosine (beta-galactosylsphingosine). Cooper, C.E., Markus, M., Seetulsingh, S.P., Wrigglesworth, J.M. Biochem. J. (1993) [Pubmed]
  19. Identification of a molecular target of psychosine and its role in globoid cell formation. Im, D.S., Heise, C.E., Nguyen, T., O'Dowd, B.F., Lynch, K.R. J. Cell Biol. (2001) [Pubmed]
  20. The role of microglia and macrophages in the pathophysiology of the CNS. Stoll, G., Jander, S. Prog. Neurobiol. (1999) [Pubmed]
  21. Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B. Sinha, S., Perdomo, G., Brown, N.F., O'Doherty, R.M. J. Biol. Chem. (2004) [Pubmed]
  22. Donor-derived cells in the central nervous system of twitcher mice after bone marrow transplantation. Hoogerbrugge, P.M., Suzuki, K., Suzuki, K., Poorthuis, B.J., Kobayashi, T., Wagemaker, G., van Bekkum, D.W. Science (1988) [Pubmed]
  23. Aspirin use and all-cause mortality among patients being evaluated for known or suspected coronary artery disease: A propensity analysis. Gum, P.A., Thamilarasan, M., Watanabe, J., Blackstone, E.H., Lauer, M.S. JAMA (2001) [Pubmed]
  24. Risk of aspirin-associated major upper-gastrointestinal bleeding with enteric-coated or buffered product. Kelly, J.P., Kaufman, D.W., Jurgelon, J.M., Sheehan, J., Koff, R.S., Shapiro, S. Lancet (1996) [Pubmed]
  25. Effect of acetylsalicylic acid on gastric mucosa. II. Mucosal ATP and phosphocreatine content, and salicylate effects on mitochondrial metabolism. Spenney, J.G., Bhown, M. Gastroenterology (1977) [Pubmed]
  26. Inhibition of cytokinesis by a lipid metabolite, psychosine. Kanazawa, T., Nakamura, S., Momoi, M., Yamaji, T., Takematsu, H., Yano, H., Sabe, H., Yamamoto, A., Kawasaki, T., Kozutsumi, Y. J. Cell Biol. (2000) [Pubmed]
  27. Trapidil (triazolopyrimidine), a platelet-derived growth factor antagonist, reduces restenosis after percutaneous transluminal coronary angioplasty. Results of the randomized, double-blind STARC study. Studio Trapidil versus Aspirin nella Restenosi Coronarica. Maresta, A., Balducelli, M., Cantini, L., Casari, A., Chioin, R., Fabbri, M., Fontanelli, A., Monici Preti, P.A., Repetto, S., De Servi, S. Circulation (1994) [Pubmed]
  28. Dramatic phenotypic improvement during pregnancy in a genetic leukodystrophy: estrogen appears to be a critical factor. Matsuda, J., Vanier, M.T., Saito, Y., Suzuki, K., Suzuki, K. Hum. Mol. Genet. (2001) [Pubmed]
  29. Lactosylceramide beta-galactosidase in human sphingolipidoses. Evidence for two genetically distinct enzymes. Tanaka, H., Suzuki, K. J. Biol. Chem. (1975) [Pubmed]
  30. HucR, a novel uric acid-responsive member of the MarR family of transcriptional regulators from Deinococcus radiodurans. Wilkinson, S.P., Grove, A. J. Biol. Chem. (2004) [Pubmed]
  31. Cyclooxygenase-2 inhibitor (SC-236) suppresses activator protein-1 through c-Jun NH2-terminal kinase. Wong, B.C., Jiang, X.H., Lin, M.C., Tu, S.P., Cui, J.T., Jiang, S.H., Wong, W.M., Yuen, M.F., Lam, S.K., Kung, H.F. Gastroenterology (2004) [Pubmed]
  32. Aspirin inhibits nuclear factor-kappa B mobilization and monocyte adhesion in stimulated human endothelial cells. Weber, C., Erl, W., Pietsch, A., Weber, P.C. Circulation (1995) [Pubmed]
  33. A large deletion together with a point mutation in the GALC gene is a common mutant allele in patients with infantile Krabbe disease. Rafi, M.A., Luzi, P., Chen, Y.Q., Wenger, D.A. Hum. Mol. Genet. (1995) [Pubmed]
  34. A mutation in the saposin A domain of the sphingolipid activator protein (prosaposin) gene results in a late-onset, chronic form of globoid cell leukodystrophy in the mouse. Matsuda, J., Vanier, M.T., Saito, Y., Tohyama, J., Suzuki, K., Suzuki, K. Hum. Mol. Genet. (2001) [Pubmed]
  35. Expression of glial fibrillary acidic protein in the CNS and PNS of murine globoid cell leukodystrophy, the twitcher. Kobayashi, S., Chiu, F.C., Katayama, M., Sacchi, R.S., Suzuki, K., Suzuki, K. Am. J. Pathol. (1986) [Pubmed]
  36. Geographic variation in the treatment of acute myocardial infarction: the Cooperative Cardiovascular Project. O'Connor, G.T., Quinton, H.B., Traven, N.D., Ramunno, L.D., Dodds, T.A., Marciniak, T.A., Wennberg, J.E. JAMA (1999) [Pubmed]
  37. Treatment of radiation-induced gastrointestinal distress with acetylsalicylate. Mennie, A.T., Dalley, V.M., Dinneen, L.C., Collier, H.O. Lancet (1975) [Pubmed]
  38. Aspirin as an adjunct to screening for prevention of sporadic colorectal cancer. A cost-effectiveness analysis. Ladabaum, U., Chopra, C.L., Huang, G., Scheiman, J.M., Chernew, M.E., Fendrick, A.M. Ann. Intern. Med. (2001) [Pubmed]
  39. Aspirin enhances the benefits of late reperfusion on infarct shape. A possible mechanism of the beneficial effects of aspirin on survival after acute myocardial infarction. Alhaddad, I.A., Tkaczevski, L., Siddiqui, F., Mir, R., Brown, E.J. Circulation (1995) [Pubmed]
  40. Hematopoietic cell transplantation in murine globoid cell leukodystrophy (the twitcher mouse): effects on levels of galactosylceramidase, psychosine, and galactocerebrosides. Ichioka, T., Kishimoto, Y., Brennan, S., Santos, G.W., Yeager, A.M. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
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