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Gene Review

MIR146A  -  microRNA 146a

Homo sapiens

Synonyms: MIRN146, MIRN146A, hsa-mir-146, hsa-mir-146a, miR-146a, ...

Disease Relevance of MIRN146a

  • miR-146a was highly expressed in an anaplastic thyroid carcinoma (ATC) samples and an ATC cell line [1]
  • A G to C polymorphism (rs2910164) in the sequence of miR-146a precursor alters predisposition to breast and ovarian cancer [2], prostate [3], thyroid [4] and hepatocellular carcinoma [5]
  • Elevated expression of miR-146a has been observed in peripheral blood mononuclear cells [6] and in synovial fibrobalsts [7] from rheumatoid arthritis patients


  1. Nuclear Factor-{kappa}B Contributes to Anaplastic Thyroid Carcinomas through Up-Regulation of miR-146a. Pacifico, F., Crescenzi, E., Mellone, S., Iannetti, A., Porrino, N., Liguoro, D., Moscato, F., Grieco, M., Formisano, S., Leonardi, A. J. Clin. Endocrinol. Metab. (2010) [Pubmed]
  2. A functional polymorphism in the miR-146a gene and age of familial breast/ovarian cancer diagnosis. Shen, J., Ambrosone, C.B., DiCioccio, R.A., Odunsi, K., Lele, S.B., Zhao, H. Carcinogenesis. (2008) [Pubmed]
  3. A functional polymorphism in Pre-miR-146a gene is associated with prostate cancer risk and mature miR-146a expression in vivo. Xu, B., Feng, N.H., Li, P.C., Tao, J., Wu, D., Zhang, Z.D., Tong, N., Wang, J.F., Song, N.H., Zhang, W., Hua, L.X., Wu, H.F. Prostate. (2009) [Pubmed]
  4. Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma. Jazdzewski, K., Murray, E.L., Franssila, K., Jarzab, B., Schoenberg, D.R., de la Chapelle, A. Proc. Natl. Acad. Sci. U. S. A. (2008) [Pubmed]
  5. A functional polymorphism in the miR-146a gene is associated with the risk for hepatocellular carcinoma. Xu, T., Zhu, Y., Wei, Q.K., Yuan, Y., Zhou, F., Ge, Y.Y., Yang, J.R., Su, H., Zhuang, S.M. Carcinogenesis. (2008) [Pubmed]
  6. Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Pauley, K.M., Satoh, M., Chan, A.L., Bubb, M.R., Reeves, W.H., Chan, E.K. Arthritis. Res. Ther. (2008) [Pubmed]
  7. Expression of microRNA-146 in rheumatoid arthritis synovial tissue. Nakasa, T., Miyaki, S., Okubo, A., Hashimoto, M., Nishida, K., Ochi, M., Asahara, H. Arthritis. Rheum. (2008) [Pubmed]
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